L-arginine and lisinopril supplementation protects against sodium fluoride–induced nephrotoxicity and hypertension by suppressing mineralocorticoid receptor and angiotensin-converting enzyme 3 activity

• Published in: Environmental science and pollution research international 2023-02, Vol.30 (9), p.23263-23275
• Main Authors: Ajibade, Temitayo Olabisi, Awodele, Olusola Adedayo, Tijani, Monsuru Oladunjoye, Adejumobi, Olumuyiwa Abiola, Adetona, Moses Olusola, Oyagbemi, Ademola Adetokunbo, Adedapo, Aduragbenro Deborah, Omobowale, Temidayo Olutayo, Aro, Abimbola Obemisola, Ola-Davies, Olufunke Eunice, Saba, Adebowale Benard, Adedapo, Adeolu Alex, Nkadimeng, Sanah Malomile, McGaw, Lyndy Joy, Kayoka-Kabongo, Prudence Ngalula, Oguntibeju, Oluwafemi Omoniyi, Yakubu, Momoh Audu
• Format: Article
• Language: English
• Subjects: Angiotensins - metabolism; Angiotensins - pharmacology; Angiotensins - therapeutic use; Animals; Antioxidants - metabolism; Aquatic Pollution; Arginine - metabolism; Arginine - pharmacology; Arginine - therapeutic use; Atmospheric Protection/Air Quality Control/Air Pollution; Blood Pressure; Dietary Supplements; Earth and Environmental Science; Ecotoxicology; Environment; Environmental Chemistry; Environmental Health; Humans; Hypertension - chemically induced; Kidney; Lisinopril - metabolism; Lisinopril - pharmacology; Lisinopril - therapeutic use; Male; Mammals; Nitric Oxide - metabolism; Oxidative Stress; Rats; Rats, Wistar; Receptors, Mineralocorticoid - metabolism; Receptors, Mineralocorticoid - therapeutic use; Research Article; Sodium Fluoride - toxicity; Waste Water Technology; Water Management; Water Pollution Control
• ISSN: 1614-7499; 1614-7499
• DOI: 10.1007/s11356-022-23784-1

Sodium fluoride (NaF) is one of the neglected environmental toxicants that has continued to silently cause toxicity to both humans and animals. NaF is universally present in water, soil, and atmosphere. The persistent and alarming rate of increase in cardiovascular and renal diseases caused by chemicals such as NaF in mammalian tissues has led to the use of various drugs for the treatment of these diseases. The present study aimed at evaluating the renoprotective and antihypertensive effects of L-arginine against NaF-induced nephrotoxicity. Thirty male Wistar rats (150–180 g) were used in this study. The rats were randomly divided into five groups of six rats each as follows: Control, NaF (300 ppm), NaF + L-arginine (100 mg/kg), NaF + L-arginine (200 mg/kg), and NaF + lisinopril (10 mg/kg). Histopathological examination and immunohistochemistry of renal angiotensin-converting enzyme (ACE) and mineralocorticoid receptor (MCR) were performed. Markers of renal damage, oxidative stress, antioxidant defense system, and blood pressure parameters were determined. L-arginine and lisinopril significantly ( P