Bisphenol A alters sexual dimorphism and gene expression in marine medaka Oryzias melastigma

Bisphenol A (BPA) is an endocrine disruptor that is present in freshwater and marine environments. However, conclusive evidence for the toxicity of chronic BPA exposure to marine fishes remains lacking. Therefore, we investigated the influence of BPA on male marine medaka ( Oryzias melastigma ). BPA...

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Published in:Environmental science and pollution research international 2023-02, Vol.30 (10), p.25691-25700
Main Authors: Yamamoto, Mitsushi, Kanazawa, Nobuhiro, Nomura, Miho, Horie, Yoshifumi, Okamura, Hideo
Format: Article
Language:English
Subjects:
Animals
Aquatic Pollution
Atmospheric Protection/Air Quality Control/Air Pollution
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Female
Gene Expression
Gonads - metabolism
Male
Oryzias - metabolism
Research Article
Sex Characteristics
Vitellogenins - metabolism
Waste Water Technology
Water Management
Water Pollutants, Chemical - metabolism
Water Pollutants, Chemical - toxicity
Water Pollution Control
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Summary:Bisphenol A (BPA) is an endocrine disruptor that is present in freshwater and marine environments. However, conclusive evidence for the toxicity of chronic BPA exposure to marine fishes remains lacking. Therefore, we investigated the influence of BPA on male marine medaka ( Oryzias melastigma ). BPA exposure induced formation of testis-ova at 2610 µg/L, and male-type anal fins became more female type in a concentration-dependent manner. Some males with female-type anal fins had normal testes, indicating that anal fin shape is more sensitive to BPA. Gonadal soma-derived factor ( gsdf ) expression decreased after BPA exposure in the 746 and 2610 µg/L exposure groups, although the changes were not statistically significant. Additionally, liver vitellogenin ( vtg ) expression increased in a dose-dependent manner and was significantly higher in all exposure groups. vtg and gsdf are likely to be useful biomarkers for the impact of estrogenic endocrine disrupters in O. melastigma .
ISSN:1614-7499
1614-7499
DOI:10.1007/s11356-022-23863-3