Antioxidant constituents in the dayflower (Commelina communis L.) and their α-glucosidase-inhibitory activity

The dayflower, Commelina communis L., contains 1-deoxynojirimycin (DNJ) and (2 R ,3 R ,4 R ,5 R )2,5-bis(hydroxymethyl)-3,4-dihydroxypyrrolidine (DMDP), potent α-glucosidase inhibitors. The extracts and powder of this herb are important food materials for prophylaxis against type 2 diabetes. Eleven...

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Bibliographic Details
Published in:Journal of natural medicines 2008-07, Vol.62 (3), p.349-353
Main Authors: Shibano, Makio, Kakutani, Koji, Taniguchi, Masahiko, Yasuda, Masahide, Baba, Kimiye
Format: Article
Language:English
Subjects:
Animals
Antioxidants - isolation & purification
Antioxidants - pharmacology
Biomedical and Life Sciences
Biomedicine
Commelina - chemistry
Complementary & Alternative Medicine
Diabetes Mellitus, Type 2 - prevention & control
Flavonoids - isolation & purification
Flavonoids - pharmacology
Free Radical Scavengers - isolation & purification
Free Radical Scavengers - pharmacology
Glycoside Hydrolase Inhibitors
Glycosides - isolation & purification
Glycosides - pharmacology
Intestines - enzymology
Intestines - metabolism
Medicinal Chemistry
Pharmacology/Toxicology
Pharmacy
Plant Components, Aerial
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Sciences
Rats
Superoxides - metabolism
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Summary:The dayflower, Commelina communis L., contains 1-deoxynojirimycin (DNJ) and (2 R ,3 R ,4 R ,5 R )2,5-bis(hydroxymethyl)-3,4-dihydroxypyrrolidine (DMDP), potent α-glucosidase inhibitors. The extracts and powder of this herb are important food materials for prophylaxis against type 2 diabetes. Eleven flavonoid glycosides as antioxidants, isoquercitrin, isorhamnetin-3- O -rutinoside, isorhamnetin-3- O -β- d -glucoside, glucoluteolin, chrysoriol-7- O -β- d -glucoside, orientin, vitexin, isoorientin, isovitexin, swertisin, and flavocommelin, were identified from the aerial parts of C. communis. Their antioxidant activities were measured using in vitro assays employing the 1,1-diphenyl-2-picrylhydrazyl radical- and superoxide radical-scavenging assays. The results showed that glucoluteolin, orientin, isoorientin, and isoquercitrin are the predominant antioxidants in this herb. Moreover, isoquercitrin, isorhamnetine-3- O -rutinoside, vitexin, and swertisin inhibited the activity of α-glucosidase from rat intestine.
ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-008-0244-1