Cytotoxic, radical scavenging and antimicrobial activities of sesquiterpenoids from the Tahitian liverwort Mastigophora diclados (Brid.) Nees (Mastigophoraceae)

• Published in: Journal of natural medicines 2010-10, Vol.64 (4), p.417-422
• Main Authors: Komala, Ismiarni, Ito, Takuya, Nagashima, Fumihiro, Yagi, Yasuyuki, Asakawa, Yoshinori
• Format: Article
• Language: English
• Subjects: Anti-Infective Agents - chemistry; Anti-Infective Agents - isolation & purification; Anti-Infective Agents - toxicity; Biomedical and Life Sciences; Biomedicine; Complementary & Alternative Medicine; Cytotoxins - chemistry; Cytotoxins - isolation & purification; Cytotoxins - toxicity; Free Radical Scavengers - chemistry; Free Radical Scavengers - isolation & purification; Free Radical Scavengers - toxicity; Hepatophyta - chemistry; Hepatophyta - toxicity; HL-60 Cells; Humans; KB Cells; Medicinal Chemistry; Original Paper; Pharmacology/Toxicology; Pharmacy; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - toxicity; Plant Sciences; Polynesia; Sesquiterpenes - chemistry; Sesquiterpenes - isolation & purification; Sesquiterpenes - toxicity
• ISSN: 1340-3443; 1861-0293
• DOI: 10.1007/s11418-010-0423-8

A drimane, (+)-drimenol ( 1 ), five known herbertanes, (−)-α-herbertenol ( 2 ), (−)-herbertenediol ( 3 ), mastigophorene A ( 4 ), (−)-mastigophorene C ( 5 ) and (−)-mastigophorene D ( 6 ), a pimarane, (−)- e nt -pimara-8(14),15-dien-19-oic acid ( 7 ), and two eudesmanolides, (−)-diplophyllolide A ( 8 ) and (−)-diplophyllin ( 9 ) were isolated from the Tahitian Mastigophora diclados (Brid.) Nees. Herbertane sesquiterpenes ( 2 , 3 , 5 and 6 ) showed cytotoxicity against HL-60 and KB cell lines, radical scavenging activity and antimicrobial activity against Bacillus subtilis . (−)-Diplophyllolide A ( 8 ) also exhibited cytotoxicity against HL-60 and KB cell lines.