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Antiobesity effect of Tamarindus indica L. pulp aqueous extract in high-fat diet-induced obese rats
Obesity and overweight are associated with atherosclerosis, fatty liver, hyperlipemia, diabetes mellitus, and various types of cancer. The global prevalence of overweight and obesity has reached epidemic proportions. Here, we investigated the effect of Tamarindus indica pulp aqueous extract (TIE) in...
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Published in: | Journal of natural medicines 2012-04, Vol.66 (2), p.333-342 |
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creator | Azman, Khairunnuur Fairuz Amom, Zulkhairi Azlan, Azrina Esa, Norhaizan Mohd Ali, Rasadah Mat Shah, Zamree Md Kadir, Khairul Kamilah Abdul |
description | Obesity and overweight are associated with atherosclerosis, fatty liver, hyperlipemia, diabetes mellitus, and various types of cancer. The global prevalence of overweight and obesity has reached epidemic proportions. Here, we investigated the effect of
Tamarindus indica
pulp aqueous extract (TIE) in diet-induced obese Sprague–Dawley rats. The animals were divided into five groups and labeled as follows: the normal control (NC) group received normal diet; the positive control (PC) group received high-fat diet; and the TIE 5, 25, and 50 groups, after the induction of obesity via a high-fat diet, received TIE at 5, 25, or 50 mg/kg orally for 10 weeks. It was observed that TIE decreased the levels of plasma total cholesterol, low-density lipoprotein (LDL), and triglyceride, and increased high-density lipoprotein (HDL), with the concomitant reduction of body weight. Moreover, TIE decreased plasma leptin and reduced fatty acid synthase (FAS) activity and enhanced the efficiency of the antioxidant defense system. TIE exhibits antiobesity effects, as indicated by a significant reduction in adipose tissue weights, as well as lowering the degree of hepatic steatosis in the obesity-induced rats. The extract possesses hepatoprotective activity, as it reversed the plasma liver enzymes level elevation prior to the high-fat diet. In conclusion, TIE improved obesity-related parameters in blood, liver, and adipose tissue in a rat model and suppressed obesity induced by a high-fat diet, possibly by regulating lipid metabolism and lowering plasma leptin and FAS levels. A dose-dependant effect of TIE is detected, where TIE at 50 mg/kg showed the most prominent effect, followed by TIE at 25 mg/kg and, subsequently, 5 mg/kg. |
doi_str_mv | 10.1007/s11418-011-0597-8 |
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Tamarindus indica
pulp aqueous extract (TIE) in diet-induced obese Sprague–Dawley rats. The animals were divided into five groups and labeled as follows: the normal control (NC) group received normal diet; the positive control (PC) group received high-fat diet; and the TIE 5, 25, and 50 groups, after the induction of obesity via a high-fat diet, received TIE at 5, 25, or 50 mg/kg orally for 10 weeks. It was observed that TIE decreased the levels of plasma total cholesterol, low-density lipoprotein (LDL), and triglyceride, and increased high-density lipoprotein (HDL), with the concomitant reduction of body weight. Moreover, TIE decreased plasma leptin and reduced fatty acid synthase (FAS) activity and enhanced the efficiency of the antioxidant defense system. TIE exhibits antiobesity effects, as indicated by a significant reduction in adipose tissue weights, as well as lowering the degree of hepatic steatosis in the obesity-induced rats. The extract possesses hepatoprotective activity, as it reversed the plasma liver enzymes level elevation prior to the high-fat diet. In conclusion, TIE improved obesity-related parameters in blood, liver, and adipose tissue in a rat model and suppressed obesity induced by a high-fat diet, possibly by regulating lipid metabolism and lowering plasma leptin and FAS levels. A dose-dependant effect of TIE is detected, where TIE at 50 mg/kg showed the most prominent effect, followed by TIE at 25 mg/kg and, subsequently, 5 mg/kg.</description><identifier>ISSN: 1340-3443</identifier><identifier>EISSN: 1861-0293</identifier><identifier>DOI: 10.1007/s11418-011-0597-8</identifier><identifier>PMID: 21989999</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Animals ; Anti-Obesity Agents - chemistry ; Anti-Obesity Agents - therapeutic use ; Biomedical and Life Sciences ; Biomedicine ; Blood Glucose - drug effects ; Body Weight - drug effects ; Complementary & Alternative Medicine ; Diet, High-Fat - adverse effects ; Eating - drug effects ; Insulin - blood ; Leptin - blood ; Male ; Medicinal Chemistry ; Obesity - blood ; Obesity - drug therapy ; Obesity - etiology ; Original Paper ; Pharmacology/Toxicology ; Pharmacy ; Plant Extracts - chemistry ; Plant Extracts - therapeutic use ; Plant Sciences ; Rats ; Rats, Sprague-Dawley ; Tamarindus - chemistry</subject><ispartof>Journal of natural medicines, 2012-04, Vol.66 (2), p.333-342</ispartof><rights>The Japanese Society of Pharmacognosy and Springer 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-7669c77ceaaef1a175585f0b2a3cc8cd6bb1539ccf92ddb73a67f4172c6e66773</citedby><cites>FETCH-LOGICAL-c335t-7669c77ceaaef1a175585f0b2a3cc8cd6bb1539ccf92ddb73a67f4172c6e66773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21989999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Azman, Khairunnuur Fairuz</creatorcontrib><creatorcontrib>Amom, Zulkhairi</creatorcontrib><creatorcontrib>Azlan, Azrina</creatorcontrib><creatorcontrib>Esa, Norhaizan Mohd</creatorcontrib><creatorcontrib>Ali, Rasadah Mat</creatorcontrib><creatorcontrib>Shah, Zamree Md</creatorcontrib><creatorcontrib>Kadir, Khairul Kamilah Abdul</creatorcontrib><title>Antiobesity effect of Tamarindus indica L. pulp aqueous extract in high-fat diet-induced obese rats</title><title>Journal of natural medicines</title><addtitle>J Nat Med</addtitle><addtitle>J Nat Med</addtitle><description>Obesity and overweight are associated with atherosclerosis, fatty liver, hyperlipemia, diabetes mellitus, and various types of cancer. The global prevalence of overweight and obesity has reached epidemic proportions. Here, we investigated the effect of
Tamarindus indica
pulp aqueous extract (TIE) in diet-induced obese Sprague–Dawley rats. The animals were divided into five groups and labeled as follows: the normal control (NC) group received normal diet; the positive control (PC) group received high-fat diet; and the TIE 5, 25, and 50 groups, after the induction of obesity via a high-fat diet, received TIE at 5, 25, or 50 mg/kg orally for 10 weeks. It was observed that TIE decreased the levels of plasma total cholesterol, low-density lipoprotein (LDL), and triglyceride, and increased high-density lipoprotein (HDL), with the concomitant reduction of body weight. Moreover, TIE decreased plasma leptin and reduced fatty acid synthase (FAS) activity and enhanced the efficiency of the antioxidant defense system. TIE exhibits antiobesity effects, as indicated by a significant reduction in adipose tissue weights, as well as lowering the degree of hepatic steatosis in the obesity-induced rats. The extract possesses hepatoprotective activity, as it reversed the plasma liver enzymes level elevation prior to the high-fat diet. In conclusion, TIE improved obesity-related parameters in blood, liver, and adipose tissue in a rat model and suppressed obesity induced by a high-fat diet, possibly by regulating lipid metabolism and lowering plasma leptin and FAS levels. A dose-dependant effect of TIE is detected, where TIE at 50 mg/kg showed the most prominent effect, followed by TIE at 25 mg/kg and, subsequently, 5 mg/kg.</description><subject>Animals</subject><subject>Anti-Obesity Agents - chemistry</subject><subject>Anti-Obesity Agents - therapeutic use</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood Glucose - drug effects</subject><subject>Body Weight - drug effects</subject><subject>Complementary & Alternative Medicine</subject><subject>Diet, High-Fat - adverse effects</subject><subject>Eating - drug effects</subject><subject>Insulin - blood</subject><subject>Leptin - blood</subject><subject>Male</subject><subject>Medicinal Chemistry</subject><subject>Obesity - blood</subject><subject>Obesity - drug therapy</subject><subject>Obesity - etiology</subject><subject>Original Paper</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Sciences</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Tamarindus - chemistry</subject><issn>1340-3443</issn><issn>1861-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kN9OwyAUxonRuDl9AG8ML8DklBbay2XxX7LEm3lNKIWNZWsr0MS9vTRVL-UCDud835ecH0L3QJdAqXgMADmUhAIQWlSClBdoDiVPv6xil6lmOSUsz9kM3YRwoDTPGINrNMugKqt05kiv2ui62gQXz9hYa3TEncVbdVLetc0QcLqdVnizxP1w7LH6HEyX2uYrepXErsV7t9sTqyJunIlkdGnT4DHUYK9iuEVXVh2Duft5F-jj-Wm7fiWb95e39WpDNGNFJILzSguhjVLGggJRFGVhaZ0ppnWpG17XULBKa1tlTVMLpriwOYhMc8O5EGyBYMrVvgvBGyt779IeZwlUjsDkBEwmYHIEJsvkeZg8_VCfTPPn-CWUBNkkCGnU7oyXh27wbdrjn9RvWNN3fQ</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>Azman, Khairunnuur Fairuz</creator><creator>Amom, Zulkhairi</creator><creator>Azlan, Azrina</creator><creator>Esa, Norhaizan Mohd</creator><creator>Ali, Rasadah Mat</creator><creator>Shah, Zamree Md</creator><creator>Kadir, Khairul Kamilah Abdul</creator><general>Springer Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20120401</creationdate><title>Antiobesity effect of Tamarindus indica L. pulp aqueous extract in high-fat diet-induced obese rats</title><author>Azman, Khairunnuur Fairuz ; Amom, Zulkhairi ; Azlan, Azrina ; Esa, Norhaizan Mohd ; Ali, Rasadah Mat ; Shah, Zamree Md ; Kadir, Khairul Kamilah Abdul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-7669c77ceaaef1a175585f0b2a3cc8cd6bb1539ccf92ddb73a67f4172c6e66773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Anti-Obesity Agents - chemistry</topic><topic>Anti-Obesity Agents - therapeutic use</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood Glucose - drug effects</topic><topic>Body Weight - drug effects</topic><topic>Complementary & Alternative Medicine</topic><topic>Diet, High-Fat - adverse effects</topic><topic>Eating - drug effects</topic><topic>Insulin - blood</topic><topic>Leptin - blood</topic><topic>Male</topic><topic>Medicinal Chemistry</topic><topic>Obesity - blood</topic><topic>Obesity - drug therapy</topic><topic>Obesity - etiology</topic><topic>Original Paper</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Sciences</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Tamarindus - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Azman, Khairunnuur Fairuz</creatorcontrib><creatorcontrib>Amom, Zulkhairi</creatorcontrib><creatorcontrib>Azlan, Azrina</creatorcontrib><creatorcontrib>Esa, Norhaizan Mohd</creatorcontrib><creatorcontrib>Ali, Rasadah Mat</creatorcontrib><creatorcontrib>Shah, Zamree Md</creatorcontrib><creatorcontrib>Kadir, Khairul Kamilah Abdul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of natural medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Azman, Khairunnuur Fairuz</au><au>Amom, Zulkhairi</au><au>Azlan, Azrina</au><au>Esa, Norhaizan Mohd</au><au>Ali, Rasadah Mat</au><au>Shah, Zamree Md</au><au>Kadir, Khairul Kamilah Abdul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiobesity effect of Tamarindus indica L. pulp aqueous extract in high-fat diet-induced obese rats</atitle><jtitle>Journal of natural medicines</jtitle><stitle>J Nat Med</stitle><addtitle>J Nat Med</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>66</volume><issue>2</issue><spage>333</spage><epage>342</epage><pages>333-342</pages><issn>1340-3443</issn><eissn>1861-0293</eissn><abstract>Obesity and overweight are associated with atherosclerosis, fatty liver, hyperlipemia, diabetes mellitus, and various types of cancer. The global prevalence of overweight and obesity has reached epidemic proportions. Here, we investigated the effect of
Tamarindus indica
pulp aqueous extract (TIE) in diet-induced obese Sprague–Dawley rats. The animals were divided into five groups and labeled as follows: the normal control (NC) group received normal diet; the positive control (PC) group received high-fat diet; and the TIE 5, 25, and 50 groups, after the induction of obesity via a high-fat diet, received TIE at 5, 25, or 50 mg/kg orally for 10 weeks. It was observed that TIE decreased the levels of plasma total cholesterol, low-density lipoprotein (LDL), and triglyceride, and increased high-density lipoprotein (HDL), with the concomitant reduction of body weight. Moreover, TIE decreased plasma leptin and reduced fatty acid synthase (FAS) activity and enhanced the efficiency of the antioxidant defense system. TIE exhibits antiobesity effects, as indicated by a significant reduction in adipose tissue weights, as well as lowering the degree of hepatic steatosis in the obesity-induced rats. The extract possesses hepatoprotective activity, as it reversed the plasma liver enzymes level elevation prior to the high-fat diet. In conclusion, TIE improved obesity-related parameters in blood, liver, and adipose tissue in a rat model and suppressed obesity induced by a high-fat diet, possibly by regulating lipid metabolism and lowering plasma leptin and FAS levels. A dose-dependant effect of TIE is detected, where TIE at 50 mg/kg showed the most prominent effect, followed by TIE at 25 mg/kg and, subsequently, 5 mg/kg.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>21989999</pmid><doi>10.1007/s11418-011-0597-8</doi><tpages>10</tpages></addata></record> |
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subjects | Animals Anti-Obesity Agents - chemistry Anti-Obesity Agents - therapeutic use Biomedical and Life Sciences Biomedicine Blood Glucose - drug effects Body Weight - drug effects Complementary & Alternative Medicine Diet, High-Fat - adverse effects Eating - drug effects Insulin - blood Leptin - blood Male Medicinal Chemistry Obesity - blood Obesity - drug therapy Obesity - etiology Original Paper Pharmacology/Toxicology Pharmacy Plant Extracts - chemistry Plant Extracts - therapeutic use Plant Sciences Rats Rats, Sprague-Dawley Tamarindus - chemistry |
title | Antiobesity effect of Tamarindus indica L. pulp aqueous extract in high-fat diet-induced obese rats |
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