Effect of Cissampelos pareira root extract on isoproterenol-induced cardiac dysfunction

• Published in: Journal of natural medicines 2013, Vol.67 (1), p.51-60
• Main Authors: Singh, Bhulan Kumar, Pillai, Krishna Kolappa, Kohli, Kanchan, Haque, Syed Ehtaishamul
• Format: Article
• Language: English
• Subjects: albino; Animals; antioxidants; Biomedical and Life Sciences; Biomedicine; blood serum; body weight; Calcineurin - blood; Cardiomegaly - blood; Cardiomegaly - drug therapy; cardioprotective effect; Cissampelos; Complementary & Alternative Medicine; drugs; glutathione; glutathione peroxidase; glutathione transferase; glutathione-disulfide reductase; heart; histopathology; Isoproterenol - toxicity; L-Lactate Dehydrogenase - metabolism; lactate dehydrogenase; Male; Medicinal Chemistry; nitric oxide; Original Paper; Oxidative Stress - drug effects; Pharmacology/Toxicology; Pharmacy; Plant Extracts - chemistry; Plant Extracts - therapeutic use; Plant Roots - chemistry; Plant Sciences; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances - metabolism; thiobarbituric acid-reactive substances
• ISSN: 1340-3443; 1861-0293
• DOI: 10.1007/s11418-012-0643-1

The aim of this study was to assess the cardioprotective effect of Cissampelos pareira root extract on isoproterenol-induced cardiac dysfunction in rats. Male albino Wistar rats were randomly divided into eight groups and received either normal saline (0.5 ml/kg, intraperitoneally), isoproterenol (5 mg/kg, intraperitoneally), C. pareira (100 and 200 mg/kg, by gavage, respectively) alone, amlodipine (9 mg/kg, by gavage) alone, C. pareira (100 and 200 mg/kg, respectively) + isoproterenol and amlodipine (9 mg/kg) + isoproterenol, once a day for 30 days, respectively. Isoproterenol-induced cardiac dysfunction was characterized by a significant (P