Tareciliosides N–S: further cycloartane saponins from the leaves of Tarenna gracilipes, and cytotoxicity of saponins and triterpenes

Six cycloartane glycosides, named tareciliosides N–S, and a known iridoid glucoside, ixoroside, were isolated in further extensive studies on the 1-BuOH-soluble fraction of a MeOH extract of the leaves of Tarenna gracilipes. From the EtOAc-soluble fraction, three known triterpenes were isolated. The...

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Bibliographic Details
Published in:Journal of natural medicines 2013-07, Vol.67 (3), p.503-511
Main Authors: Zhao, Zhimin, Matsunami, Katsuyoshi, Otsuka, Hideaki, Shinzato, Takakazu, Takeda, Yoshio
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Biomedical and Life Sciences
Biomedicine
Cell Line, Tumor
Cell Survival - drug effects
Complementary & Alternative Medicine
cytotoxicity
Dose-Response Relationship, Drug
Glycosides - chemistry
Glycosides - isolation & purification
Glycosides - pharmacology
Humans
Inhibitory Concentration 50
leaves
Leishmania major
Leishmania major - drug effects
Lung Neoplasms
Medicinal Chemistry
Molecular Structure
Original Paper
Pharmacology/Toxicology
Pharmacy
Phytotherapy
Plant Extracts - chemistry
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Plant Leaves - chemistry
Plant Sciences
Plants, Medicinal
Rubiaceae - chemistry
Saponins - chemistry
Saponins - isolation & purification
Saponins - pharmacology
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - pharmacology
triterpenoid saponins
Trypanocidal Agents - chemistry
Trypanocidal Agents - isolation & purification
Trypanocidal Agents - pharmacology
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Summary:Six cycloartane glycosides, named tareciliosides N–S, and a known iridoid glucoside, ixoroside, were isolated in further extensive studies on the 1-BuOH-soluble fraction of a MeOH extract of the leaves of Tarenna gracilipes. From the EtOAc-soluble fraction, three known triterpenes were isolated. Their toxicities toward A549 and Leishmania major trypanosome protozoa were assayed. Triterpenes were selectively active in the two organisms.
ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-012-0707-2