2,3,5-Trimethoxy-4-cresol, an anti-metastatic constituent from the solid-state cultured mycelium of Antrodia cinnamomea and its mechanism

Antrodia cinnamomea is a valuable and unique edible fungus originating from the forests of Taiwan. In this study, an anti-metastatic compound, 2,3,5-trimethoxy-4-cresol (TMC), was isolated from the solid-state cultured mycelium of A. cinnamomea. According to the results obtained from cell wound heal...

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Bibliographic Details
Published in:Journal of natural medicines 2015-10, Vol.69 (4), p.513-521
Main Authors: Lin, Chin-Chung, Chen, Ching-Chun, Kuo, Yueh-Hsiung, Kuo, Jong-Tar, Senthil Kumar, K. J, Wang, Sheng-Yang
Format: Article
Language:English
Subjects:
Antrodia - chemistry
Biomedical and Life Sciences
Biomedicine
cadherins
Carcinoma, Non-Small-Cell Lung - drug therapy
Carcinoma, Non-Small-Cell Lung - mortality
cell adhesion
cell movement
Complementary & Alternative Medicine
edible fungi
Epithelial-Mesenchymal Transition
forests
Humans
lung neoplasms
Lung Neoplasms - drug therapy
Lung Neoplasms - mortality
Medicinal Chemistry
metastasis
migration
mycelium
Mycelium - chemistry
neoplasm cells
Original Paper
Pharmacology/Toxicology
Pharmacy
Plant Sciences
Plants, Medicinal - chemistry
protein synthesis
Taiwanofungus camphoratus
tissue repair
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Summary:Antrodia cinnamomea is a valuable and unique edible fungus originating from the forests of Taiwan. In this study, an anti-metastatic compound, 2,3,5-trimethoxy-4-cresol (TMC), was isolated from the solid-state cultured mycelium of A. cinnamomea. According to the results obtained from cell wound healing, cell migration and invasion assays, TMC effectively suppressed movement, migration and invasion of lung cancer cells at the dosage of 5–40 μM, which was non-toxic to A549 cells. In addition, TMC reduced protein expression of Akt, MMP-2 and MMP-9 and enhanced E-cadherin and TIMP-1 protein expression, which are known to regulate cell adhesion, migration and invasion. Taken together, TMC effectively suppresses movement, migration and invasion of lung cancer cells, and achieves an anti-cancer metastasis effect.
ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-015-0916-6