Methoxy poly(ethylene glycol)-b-poly(ethyl cyanoacrylate) copolymer nanoparticles as delivery vehicles for dexamethasone

Methoxy poly(ethylene oxide)-b-poly(ethyl cyanoacrylate) (mPEG-b-PECA), amphiphilic block copolymer, was synthesized via oxyanion-initiated polymerization with a sodium alcoholate-terminated monomethoxy poly(ethylene glycol) as the macroinitiator. mPEG-b-PECA was characterized by GPC, 1 H-NMR and FT...

Full description

Saved in:
Bibliographic Details
Published in:Chinese science bulletin 2009-09, Vol.54 (17), p.2918-2924
Main Authors: Zhai, YingLei, Deng, LianDong, Lin, XiaoNa, Xiao, Li, Jin, FengMin, Dong, AnJie
Format: Article
Language:English
Subjects:
Chemistry/Food Science
Earth Sciences
Engineering
Humanities and Social Sciences
Life Sciences
multidisciplinary
Physics
Science
Science (multidisciplinary)
Special Topic/Articles/Biomedical Materials
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Methoxy poly(ethylene oxide)-b-poly(ethyl cyanoacrylate) (mPEG-b-PECA), amphiphilic block copolymer, was synthesized via oxyanion-initiated polymerization with a sodium alcoholate-terminated monomethoxy poly(ethylene glycol) as the macroinitiator. mPEG-b-PECA was characterized by GPC, 1 H-NMR and FTIR. The results indicate that the structure of mPEG-b-PECA is well controlled with narrow molecular weight distribution. The dexamethasone (DXM)-loaded mPEG-b-PECA nanoparticles (NPs) were prepared by the nanoprecipitation technique and characterized by LPSA, 1 H-NMR and TEM. The DXM-loaded mPEG-b-PECA NPs are of spherical shape with the size of less than 100 nm. The drug-loaded amount (DL) and encapsulation efficiency (EE) of DXM-loaded NPs were investigated by HPLC. The results show that DXM can be effectively incorporated into mPEG-b-PECA NPs, which provides a potential delivery system for DXM and other hydrophobic drugs.
ISSN:1001-6538
1861-9541
DOI:10.1007/s11434-009-0246-8