Star-shaped conjugated oligoelectrolyte for bioimaging in living cells

A new star-shaped oligoelectrolyte (TEFCOONa) with triphenylamine as the core, acetylene as linkage and anionic fluorenes as arms was obtained and used for direct imaging in living PANC-1 cells. Because of the hydrophobic conjugated groups of the oligoelectrolyte, TEFCOONa can form nanospheres with...

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Bibliographic Details
Published in:Chinese science bulletin 2013-07, Vol.58 (21), p.2570-2575
Main Authors: Song, WenLi, Jiang, RongCui, Yuan, Yan, Lu, XiaoMei, Hu, WenBo, Fan, QuLi, Huang, Wei
Format: Article
Language:English
Subjects:
acetylene
Chemistry/Food Science
cytoplasm
cytotoxicity
Earth Sciences
Engineering
Humanities and Social Sciences
image analysis
Life Sciences
multidisciplinary
nanospheres
Physics
Science
Science (multidisciplinary)
共轭
平均直径
星形
活细胞成像
生物成像
直接成像
纳米微球
超支化聚合物
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Summary:A new star-shaped oligoelectrolyte (TEFCOONa) with triphenylamine as the core, acetylene as linkage and anionic fluorenes as arms was obtained and used for direct imaging in living PANC-1 cells. Because of the hydrophobic conjugated groups of the oligoelectrolyte, TEFCOONa can form nanospheres with an average diameter of ∼75 nm in 10 mmol/L PBS. These nanospheres possess a relatively high absolute quantum yield (16.5% in PBS), low cytotoxicity and can penetrate into the nucleus through the cytoplasm, which is essential for living cellular imaging. Collectively, these results validate our rational design of conjugated oligoelectrolyte and even hyper branched polymers-copolyelectrolyte as effective nanovectors for bioimaging and other clinical applications.
ISSN:1001-6538
1861-9541
DOI:10.1007/s11434-013-5796-0