Drug release behaviors of a pH/temperature sensitive core-shelled bead with alginate and poly( N-acryloyl glycinates)

• Published in: Frontiers of materials science 2010-12, Vol.4 (4), p.353-358
• Main Authors: DENG, Kui-Lin, GOU, Yu-Bo, DONG, Li-Rong, LI, Qian, BAI, Li-Bin, GAO, Ting, HUANG, Chun-Yuan, WANG, Shu-Liang
• Format: Article
• Language: English
• Subjects: Chemistry and Materials Science; core-shelled structure; drug release; Materials Science; pH/temperature sensitive bead; Research Article; sodium alginate
• ISSN: 2095-025X; 1673-7377; 2095-0268; 1673-7482
• DOI: 10.1007/s11706-010-0105-1

In this study, a pH/temperature sensitive bead with core-shelled structure, as a drug carrier, was prepared by grafting of N-acryloylglycinates on the surface of sodium alginate beads. The pH and temperature sensitivity of the beads originate from sodium alginate (SA) and co-poly( N-acryloylglycinates), respectively. Here, indomethacin (IMC) was selected as a drug model molecule and loaded in SA beads. The release of IMC was systematically investigated as a function of temperature, pH, and SA concentration. The amount of IMC released from beads was as high as 61.6% in pH= 7.4 phosphate buffer solution (PBS) over 620 min, whereas only 27.9% IMC diffused into the pH= 2.1 PBS. In addition, the release rates of IMC at 37.5°C were faster than that at 20.0°C and decreased with increasing SA concentration in the beads. The result indicates that the sensitive beads have the potential to be used as an effective pH/temperature-controlled delivery system in the biomedical fields.