Loading…

Synthesis, characterization and biological evaluation of poly [LA-co-(Glc-alt-Lys)] for nerve regeneration scaffold

A novel nerve repairing material poly [LA-co-(Glc-alt-Lys)] (PLGL) was synthesized. The viability and growth of Schwann cells (SCs) co-cultured with poly (D, L-lactic acid) (PDLLA) films (control group) and PLGL films were evaluated by MTT assay and SEM observation. Then, contact angle measurement,...

Full description

Saved in:

Bibliographic Details
Published in:	Frontiers of materials science 2014, Vol.8 (1), p.95-101
Main Authors:	YIN, Yi-Xia, YI, Ji-Ling, XIE, Li-Juan, YAN, Qiong-Jiao, DAI, Hong-Lian, LI, Shi-Pu
Format:	Article
Language:	English
Subjects:	biocompatibility Chemistry and Materials Science implantation inflammatory factor Materials Science poly [LA-co-(Glc-alt-Lys)] (PLGL) Research Article Schwann cell (SC)
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

cited_by	cdi_FETCH-LOGICAL-c337t-2bb5d25a02a878c3845c7c1e757eb8dc55c1fdfa084ce434597ff4c03cb9222b3
cites	cdi_FETCH-LOGICAL-c337t-2bb5d25a02a878c3845c7c1e757eb8dc55c1fdfa084ce434597ff4c03cb9222b3
container_end_page	101
container_issue	1
container_start_page	95
container_title	Frontiers of materials science
container_volume	8
creator	YIN, Yi-Xia YI, Ji-Ling XIE, Li-Juan YAN, Qiong-Jiao DAI, Hong-Lian LI, Shi-Pu
description	A novel nerve repairing material poly [LA-co-(Glc-alt-Lys)] (PLGL) was synthesized. The viability and growth of Schwann cells (SCs) co-cultured with poly (D, L-lactic acid) (PDLLA) films (control group) and PLGL films were evaluated by MTT assay and SEM observation. Then, contact angle measurement, histological assessment and enzyme-linked immunosorbent assay (ELISA) testing on inflammatory-related cytokines such as IL-10 and TGF-β1 were performed. The results showed that, compared with PDLLA, PLGL films possesses better hydrophilicity, biocompatibility, degradation property and less inflammatory reaction. The present study indicated that PLGL scaffolds would meet the requirements of artificial nerve scaffold and have a potential application in the fields of nerve regeneration.
doi_str_mv	10.1007/s11706-014-0239-7
format	article
fullrecord	<record><control><sourceid>higheredpress_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1007_s11706_014_0239_7</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10.1007/s11706-014-0239-7</sourcerecordid><originalsourceid>FETCH-LOGICAL-c337t-2bb5d25a02a878c3845c7c1e757eb8dc55c1fdfa084ce434597ff4c03cb9222b3</originalsourceid><addsrcrecordid>eNp9kFFLwzAQgIMoOOZ-gG95VDCapM3SPo6hUyj4oIIgEtL00nbEZiSdUH-9HRUfdy93x913HB9Cl4zeMkrlXWRM0iWhLCWUJzmRJ2jGaS7Gbpmd_tfi_RwtYtzSMQQTecpmKL4MXd9AbOMNNo0O2vQQ2h_dt77Duqtw2Xrn69Zoh-Fbu_008RbvvBvwR7EixpOrjTNEu54UQ7z-xNYH3EH4BhyghrGaoGi0td5VF-jMahdh8Zfn6O3h_nX9SIrnzdN6VRCTJLInvCxFxYWmXGcyM0mWCiMNAykklFllhDDMVlbTLDWQJqnIpbWpoYkpc855mcwRm-6a4GMMYNUutF86DIpRdRCnJnFqFKcO4pQcGT4xcdztaghq6_ehG988CmUT1LR1AwGqXYAYlQ2-61sIx9BfoZOEbg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Synthesis, characterization and biological evaluation of poly [LA-co-(Glc-alt-Lys)] for nerve regeneration scaffold</title><source>Springer Link</source><creator>YIN, Yi-Xia ; YI, Ji-Ling ; XIE, Li-Juan ; YAN, Qiong-Jiao ; DAI, Hong-Lian ; LI, Shi-Pu</creator><creatorcontrib>YIN, Yi-Xia ; YI, Ji-Ling ; XIE, Li-Juan ; YAN, Qiong-Jiao ; DAI, Hong-Lian ; LI, Shi-Pu</creatorcontrib><description>A novel nerve repairing material poly [LA-co-(Glc-alt-Lys)] (PLGL) was synthesized. The viability and growth of Schwann cells (SCs) co-cultured with poly (D, L-lactic acid) (PDLLA) films (control group) and PLGL films were evaluated by MTT assay and SEM observation. Then, contact angle measurement, histological assessment and enzyme-linked immunosorbent assay (ELISA) testing on inflammatory-related cytokines such as IL-10 and TGF-β1 were performed. The results showed that, compared with PDLLA, PLGL films possesses better hydrophilicity, biocompatibility, degradation property and less inflammatory reaction. The present study indicated that PLGL scaffolds would meet the requirements of artificial nerve scaffold and have a potential application in the fields of nerve regeneration.</description><identifier>ISSN: 2095-025X</identifier><identifier>EISSN: 2095-0268</identifier><identifier>DOI: 10.1007/s11706-014-0239-7</identifier><language>eng</language><publisher>Heidelberg: Higher Education Press</publisher><subject>biocompatibility ; Chemistry and Materials Science ; implantation ; inflammatory factor ; Materials Science ; poly [LA-co-(Glc-alt-Lys)] (PLGL) ; Research Article ; Schwann cell (SC)</subject><ispartof>Frontiers of materials science, 2014, Vol.8 (1), p.95-101</ispartof><rights>Copyright reserved, 2014, Higher Education Press and Springer-Verlag Berlin Heidelberg</rights><rights>Higher Education Press and Springer-Verlag Berlin Heidelberg 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-2bb5d25a02a878c3845c7c1e757eb8dc55c1fdfa084ce434597ff4c03cb9222b3</citedby><cites>FETCH-LOGICAL-c337t-2bb5d25a02a878c3845c7c1e757eb8dc55c1fdfa084ce434597ff4c03cb9222b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>YIN, Yi-Xia</creatorcontrib><creatorcontrib>YI, Ji-Ling</creatorcontrib><creatorcontrib>XIE, Li-Juan</creatorcontrib><creatorcontrib>YAN, Qiong-Jiao</creatorcontrib><creatorcontrib>DAI, Hong-Lian</creatorcontrib><creatorcontrib>LI, Shi-Pu</creatorcontrib><title>Synthesis, characterization and biological evaluation of poly [LA-co-(Glc-alt-Lys)] for nerve regeneration scaffold</title><title>Frontiers of materials science</title><addtitle>Front. Mater. Sci</addtitle><description>A novel nerve repairing material poly [LA-co-(Glc-alt-Lys)] (PLGL) was synthesized. The viability and growth of Schwann cells (SCs) co-cultured with poly (D, L-lactic acid) (PDLLA) films (control group) and PLGL films were evaluated by MTT assay and SEM observation. Then, contact angle measurement, histological assessment and enzyme-linked immunosorbent assay (ELISA) testing on inflammatory-related cytokines such as IL-10 and TGF-β1 were performed. The results showed that, compared with PDLLA, PLGL films possesses better hydrophilicity, biocompatibility, degradation property and less inflammatory reaction. The present study indicated that PLGL scaffolds would meet the requirements of artificial nerve scaffold and have a potential application in the fields of nerve regeneration.</description><subject>biocompatibility</subject><subject>Chemistry and Materials Science</subject><subject>implantation</subject><subject>inflammatory factor</subject><subject>Materials Science</subject><subject>poly [LA-co-(Glc-alt-Lys)] (PLGL)</subject><subject>Research Article</subject><subject>Schwann cell (SC)</subject><issn>2095-025X</issn><issn>2095-0268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp9kFFLwzAQgIMoOOZ-gG95VDCapM3SPo6hUyj4oIIgEtL00nbEZiSdUH-9HRUfdy93x913HB9Cl4zeMkrlXWRM0iWhLCWUJzmRJ2jGaS7Gbpmd_tfi_RwtYtzSMQQTecpmKL4MXd9AbOMNNo0O2vQQ2h_dt77Duqtw2Xrn69Zoh-Fbu_008RbvvBvwR7EixpOrjTNEu54UQ7z-xNYH3EH4BhyghrGaoGi0td5VF-jMahdh8Zfn6O3h_nX9SIrnzdN6VRCTJLInvCxFxYWmXGcyM0mWCiMNAykklFllhDDMVlbTLDWQJqnIpbWpoYkpc855mcwRm-6a4GMMYNUutF86DIpRdRCnJnFqFKcO4pQcGT4xcdztaghq6_ehG988CmUT1LR1AwGqXYAYlQ2-61sIx9BfoZOEbg</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>YIN, Yi-Xia</creator><creator>YI, Ji-Ling</creator><creator>XIE, Li-Juan</creator><creator>YAN, Qiong-Jiao</creator><creator>DAI, Hong-Lian</creator><creator>LI, Shi-Pu</creator><general>Higher Education Press</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2014</creationdate><title>Synthesis, characterization and biological evaluation of poly [LA-co-(Glc-alt-Lys)] for nerve regeneration scaffold</title><author>YIN, Yi-Xia ; YI, Ji-Ling ; XIE, Li-Juan ; YAN, Qiong-Jiao ; DAI, Hong-Lian ; LI, Shi-Pu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-2bb5d25a02a878c3845c7c1e757eb8dc55c1fdfa084ce434597ff4c03cb9222b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>biocompatibility</topic><topic>Chemistry and Materials Science</topic><topic>implantation</topic><topic>inflammatory factor</topic><topic>Materials Science</topic><topic>poly [LA-co-(Glc-alt-Lys)] (PLGL)</topic><topic>Research Article</topic><topic>Schwann cell (SC)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YIN, Yi-Xia</creatorcontrib><creatorcontrib>YI, Ji-Ling</creatorcontrib><creatorcontrib>XIE, Li-Juan</creatorcontrib><creatorcontrib>YAN, Qiong-Jiao</creatorcontrib><creatorcontrib>DAI, Hong-Lian</creatorcontrib><creatorcontrib>LI, Shi-Pu</creatorcontrib><collection>CrossRef</collection><jtitle>Frontiers of materials science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YIN, Yi-Xia</au><au>YI, Ji-Ling</au><au>XIE, Li-Juan</au><au>YAN, Qiong-Jiao</au><au>DAI, Hong-Lian</au><au>LI, Shi-Pu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis, characterization and biological evaluation of poly [LA-co-(Glc-alt-Lys)] for nerve regeneration scaffold</atitle><jtitle>Frontiers of materials science</jtitle><stitle>Front. Mater. Sci</stitle><date>2014</date><risdate>2014</risdate><volume>8</volume><issue>1</issue><spage>95</spage><epage>101</epage><pages>95-101</pages><issn>2095-025X</issn><eissn>2095-0268</eissn><abstract>A novel nerve repairing material poly [LA-co-(Glc-alt-Lys)] (PLGL) was synthesized. The viability and growth of Schwann cells (SCs) co-cultured with poly (D, L-lactic acid) (PDLLA) films (control group) and PLGL films were evaluated by MTT assay and SEM observation. Then, contact angle measurement, histological assessment and enzyme-linked immunosorbent assay (ELISA) testing on inflammatory-related cytokines such as IL-10 and TGF-β1 were performed. The results showed that, compared with PDLLA, PLGL films possesses better hydrophilicity, biocompatibility, degradation property and less inflammatory reaction. The present study indicated that PLGL scaffolds would meet the requirements of artificial nerve scaffold and have a potential application in the fields of nerve regeneration.</abstract><cop>Heidelberg</cop><pub>Higher Education Press</pub><doi>10.1007/s11706-014-0239-7</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext	fulltext
identifier	ISSN: 2095-025X
ispartof	Frontiers of materials science, 2014, Vol.8 (1), p.95-101
issn	2095-025X 2095-0268
language	eng
recordid	cdi_crossref_primary_10_1007_s11706_014_0239_7
source	Springer Link
subjects	biocompatibility Chemistry and Materials Science implantation inflammatory factor Materials Science poly [LA-co-(Glc-alt-Lys)] (PLGL) Research Article Schwann cell (SC)
title	Synthesis, characterization and biological evaluation of poly [LA-co-(Glc-alt-Lys)] for nerve regeneration scaffold
url	http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T03%3A48%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-higheredpress_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthesis,%20characterization%20and%20biological%20evaluation%20of%20poly%20%5BLA-co-(Glc-alt-Lys)%5D%20for%20nerve%20regeneration%20scaffold&rft.jtitle=Frontiers%20of%20materials%20science&rft.au=YIN,%20Yi-Xia&rft.date=2014&rft.volume=8&rft.issue=1&rft.spage=95&rft.epage=101&rft.pages=95-101&rft.issn=2095-025X&rft.eissn=2095-0268&rft_id=info:doi/10.1007/s11706-014-0239-7&rft_dat=%3Chigheredpress_cross%3E10.1007/s11706-014-0239-7%3C/higheredpress_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c337t-2bb5d25a02a878c3845c7c1e757eb8dc55c1fdfa084ce434597ff4c03cb9222b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true