The up‐regulation of hepatic acyl‐coA oxidase and cytochrome P 450 4A1 mRNA expression by dietary oxidized frying oil is comparable between male and female rats

We previously demonstrated that oxidized frying oil (OFO) activates peroxisome proliferator‐activated receptor α (PPARα) and up‐regulates hepatic acyl‐CoA oxidase (ACO) and cytochrome P 450 4A1 (CYP4A1) genes in male rats. As female rats were shown to be less responsive to some peroxisome proliferat...

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Bibliographic Details
Published in:Lipids 2004-03, Vol.39 (3), p.233-238
Main Authors: Chao, Pei‐Min, Hsu, Shan‐Ching, Lin, Fu‐Jung, Li, Yi‐Jen, Huang, Ching‐jang
Format: Article
Language:English
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Summary:We previously demonstrated that oxidized frying oil (OFO) activates peroxisome proliferator‐activated receptor α (PPARα) and up‐regulates hepatic acyl‐CoA oxidase (ACO) and cytochrome P 450 4A1 (CYP4A1) genes in male rats. As female rats were shown to be less responsive to some peroxisome proliferators (PP), this study compared the expression of a few PPARα target genes in male and female rats fed diets containing OFO. Male and female rats were fed a diet containing 20 g/100 g OFO (O diet) or fresh soybean oil (F diet) for 6 wk. Both male and female rats fed the O diet showed significantly higher liver weight, hepatic ACO and catalase activities, CYP4A protein, and expression of ACO and CYP4A1 mRNA ( P
ISSN:0024-4201
1558-9307
DOI:10.1007/s11745-004-1224-4