Selection of alcohols through Plackett‐Burman design in lipase‐catalyzed synthesis of anthranilic acid esters

Lipase‐catalyzed synthesis of esters of anthranilic acid was attempted by employing alcohols of carbon chainlength C1–C18 using Plackett‐Burman experimental design. Of the alcohols employed, methanol, decanol, cetyl alcohol, and stearyl alcohols showed 99.9% significance. Esterification of anthranil...

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Bibliographic Details
Published in:Journal of the American Oil Chemists' Society 2001-01, Vol.78 (1), p.49-52
Main Authors: Babu, C. V. Suresh, Divakar, S.
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Anthranilic acid esters
Applied sciences
Biological and medical sciences
Chemical industry and chemicals
Enzymes and enzyme inhibitors
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
Hydrolases
Manufacturing and processing
methyl anthranilate and porcine pancreas lipase
Oils and fats
Plackett‐Burman design
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Summary:Lipase‐catalyzed synthesis of esters of anthranilic acid was attempted by employing alcohols of carbon chainlength C1–C18 using Plackett‐Burman experimental design. Of the alcohols employed, methanol, decanol, cetyl alcohol, and stearyl alcohols showed 99.9% significance. Esterification of anthranilic acid with methanol gave the highest yield at 45.6%. This study allows the selection of better alcohols for esterification of anthranilic acid.
ISSN:0003-021X
1558-9331
DOI:10.1007/s11746-001-0218-y