ICORG 06-35: a prospective evaluation of PET-CT scan in patients with non-operable or non-resectable non-small cell lung cancer treated by radical 3-dimensional conformal radiation therapy: a phase II study

Background Radiotherapy (RT) is a key treatment modality in the curative treatment of patients with non-small cell lung cancer (NSCLC). Incorrect definition of the gross, or clinical, target volume is a common source of error which can lead to a reduced probability of tumour control. Objective This...

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Bibliographic Details
Published in:Irish journal of medical science 2019-11, Vol.188 (4), p.1155-1161
Main Authors: Lee, Karla A., Rangaswamy, Guhan, Lavan, Naomi A., Dunne, Mary, Collins, Conor D., Small, Cormac, Thirion, Pierre
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Non-Small-Cell Lung - radiotherapy
Family Medicine
Female
General Practice
Humans
Internal Medicine
Lung Neoplasms - pathology
Lung Neoplasms - radiotherapy
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Recurrence, Local
Original Article
Pilot Projects
Positron Emission Tomography Computed Tomography - methods
Prospective Studies
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Conformal - methods
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Summary:Background Radiotherapy (RT) is a key treatment modality in the curative treatment of patients with non-small cell lung cancer (NSCLC). Incorrect definition of the gross, or clinical, target volume is a common source of error which can lead to a reduced probability of tumour control. Objective This was a pilot and a phase II study. The pilot evaluated the technical feasibility of integrating positron emission tomography–computed tomography (PET-CT) fusion. The primary outcome of the phase II study was to evaluate the safety of PET-CT scan–based RT by evaluating the rate of loco-regional recurrence outside the PET-CT planning target volume (PTV) but within conventional 3-D PTV. Methods Patients underwent standard post-treatment follow-up, including repeated three monthly CT scans of the thorax. In case of loco-regional recurrence, three categories were considered, with only extra-PET scan PTV and intra-CT scan PTV recurrences considered as a failure. Our hypothesis was that the rate of these events would be
ISSN:0021-1265
1863-4362
DOI:10.1007/s11845-019-02019-2