Chronic Toxic Metal Exposure and Cardiovascular Disease: Mechanisms of Risk and Emerging Role of Chelation Therapy

Over the last few decades, there has been a growing body of epidemiologic evidence linking chronic toxic metal exposure to cardiovascular disease-related morbidity and mortality. The recent and unexpectedly positive findings from a randomized, double-blind, multicenter trial of metal chelation for t...

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Bibliographic Details
Published in:Current atherosclerosis reports 2016-12, Vol.18 (12), p.81, Article 81
Main Authors: Aneni, Ehimen C., Escolar, Esteban, Lamas, Gervasio A.
Format: Article
Language:English
Subjects:
Angiology
Cardiology
Cardiovascular Diseases - etiology
Cardiovascular Diseases - prevention & control
Chelating Agents - therapeutic use
Chelation Therapy
Heavy Metal Poisoning
Humans
Medicine
Medicine & Public Health
Nonstatin Drugs (E. deGoma
Poisoning - complications
Poisoning - drug therapy
Risk
Secondary Prevention
Section Editor
Topical Collection on Nonstatin Drugs
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Summary:Over the last few decades, there has been a growing body of epidemiologic evidence linking chronic toxic metal exposure to cardiovascular disease-related morbidity and mortality. The recent and unexpectedly positive findings from a randomized, double-blind, multicenter trial of metal chelation for the secondary prevention of atherosclerotic cardiovascular disease (Trial to Assess Chelation Therapy (TACT)) have focused the discussion on the role of chronic exposure to toxic metals in the development and propagation of cardiovascular disease and the role of toxic metal chelation therapy in the secondary prevention of cardiovascular disease. This review summarizes the most recent evidence linking chronic toxic metal exposure to cardiovascular disease and examines the findings of TACT.
ISSN:1523-3804
1534-6242
DOI:10.1007/s11883-016-0631-0