Role of Exercise in NAFLD/NASH: What is the Right Prescription?

Purpose of Review Non-alcoholic fatty liver disease is the most prevalent liver disease worldwide and is associated with increased mortality risk related to cardiovascular and liver disease. We aim to review the current evidence regarding the role of exercise in non-alcoholic fatty liver disease (NA...

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Bibliographic Details
Published in:Current hepatology reports 2017-12, Vol.16 (4), p.356-365
Main Authors: Bertot, Luis Calzadilla, Adams, Leon Anton
Format: Article
Language:English
Subjects:
Fatty Liver Disease (S Harrison and J George
Hepatology
Medicine
Medicine & Public Health
Section Editors
Topical Collection on Fatty Liver Disease
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Summary:Purpose of Review Non-alcoholic fatty liver disease is the most prevalent liver disease worldwide and is associated with increased mortality risk related to cardiovascular and liver disease. We aim to review the current evidence regarding the role of exercise in non-alcoholic fatty liver disease (NAFLD), which is the current cornerstone of treatment in conjunction with diet. Recent Findings Regular moderate- and high-intensity exercise improve intrahepatic steatosis by 2–10% with no significant difference between aerobic and resistance programs. The optimal duration, intensity, and volume required for improvement of non-alcoholic steatohepatitis (NASH) and fibrosis are unknown. Benefits of exercise extend beyond the liver to improve cardiovascular risk profiles, insulin resistance, and obesity, which are all linked directly to NASH. Summary Exercise type (aerobic versus resistance), dosage, and duration should be tailored considering age, adherence, and comorbidities and should be combined with specific dietary modifications.
ISSN:2195-9595
2195-9595
DOI:10.1007/s11901-017-0374-6