A missense polymorphism (rs11466653, Met326Thr) of toll-like receptor 10 (TLR10) is associated with tumor size of papillary thyroid carcinoma in the Korean population

• Published in: Endocrine 2013-02, Vol.43 (1), p.161-169
• Main Authors: Kim, Su Kang, Park, Hae Jeong, Hong, Il Ki, Chung, Joo-Ho, Eun, Young Gyu
• Format: Article
• Language: English
• Subjects: Adult; Aged; Alleles; Amino Acid Substitution; Carcinoma - genetics; Carcinoma - metabolism; Carcinoma - pathology; Carcinoma, Papillary - genetics; Carcinoma, Papillary - metabolism; Carcinoma, Papillary - pathology; Diabetes; Endocrinology; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Humanities and Social Sciences; Humans; Internal Medicine; Linkage Disequilibrium; Male; Medicine; Medicine & Public Health; Middle Aged; multidisciplinary; Original Article; Polymorphism, Single Nucleotide; Republic of Korea; Science; Thyroid Neoplasms - genetics; Thyroid Neoplasms - metabolism; Thyroid Neoplasms - pathology; Toll-Like Receptor 1 - genetics; Toll-Like Receptor 1 - metabolism; Toll-Like Receptor 10 - genetics; Toll-Like Receptor 10 - metabolism; Toll-Like Receptor 6 - genetics; Toll-Like Receptor 6 - metabolism; Tumor Burden
• ISSN: 1355-008X; 1559-0100
• DOI: 10.1007/s12020-012-9783-z

Toll-like receptors (TLRs) are important components of innate immune response. The aim of this study was to investigate whether TLR gene cluster ( TLR10 - TLR1 - TLR6 ) polymorphisms are associated with the etiology of papillary thyroid carcinoma (PTC) and its clinicopathologic characteristics. We recruited 94 PTC patients and 325 control subjects. Genotypes for each SNP were determined by direct sequencing. SNPStats and SPSS 18.0 were used to evaluate odds ratios (ORs), 95 % confidence intervals (CIs), and P values. Multiple logistic regression analyzes of genetic data were performed. The missense SNP rs11466653 was associated with small tumor size (