Perioperative androstenedione kinetics in women undergoing laparoscopic ovarian drilling: a prospective study

We evaluated perioperative androstenedione levels in laparoscopic ovarian drilling (LOD) for polycystic ovary syndrome (PCOS) and whether an intraoperative androstenedione change was predictive for spontaneous ovulation. In a prospective study, 21 anovulatory women with clomiphene citrate-resistant...

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Bibliographic Details
Published in:Endocrine 2014-12, Vol.47 (3), p.936-942
Main Authors: Ott, Johannes, Mayerhofer, Klaus, Nouri, Kazem, Walch, Katharina, Seemann, Rudolf, Kurz, Christine
Format: Article
Language:English
Subjects:
Adult
Androstenedione - blood
Androstenedione - pharmacokinetics
Androstenedione - therapeutic use
Diabetes
Endocrinology
Female
Fertility Agents, Female - blood
Fertility Agents, Female - pharmacokinetics
Fertility Agents, Female - therapeutic use
Gynecologic Surgical Procedures
Humanities and Social Sciences
Humans
Internal Medicine
Laparoscopy
Medicine
Medicine & Public Health
multidisciplinary
Original Article
Perioperative Period
Polycystic Ovary Syndrome - blood
Polycystic Ovary Syndrome - drug therapy
Polycystic Ovary Syndrome - surgery
Prospective Studies
Science
Treatment Outcome
Young Adult
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Summary:We evaluated perioperative androstenedione levels in laparoscopic ovarian drilling (LOD) for polycystic ovary syndrome (PCOS) and whether an intraoperative androstenedione change was predictive for spontaneous ovulation. In a prospective study, 21 anovulatory women with clomiphene citrate-resistant PCOS who underwent LOD and eight female controls who underwent diagnostic laparoscopy for infertility were included. Perioperatively, blood was drawn one day before surgery, directly before skin incision, ten minutes after surgery, and after two days. Within three months, spontaneous ovulation occurred in 15 women (71.4 %). For both the PCOS and the control group, an androstenedione increase was found from one day before surgery to skin incision ( p  
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-014-0267-1