The Prevalence of the Mutation in Codon 249 of the P53 Gene in Patients with Hepatocellular Carcinoma (HCC) in Turkey

  Hepatocellular carcinoma (HCC) is one of the most common cancers in the worldwide. Aflotoxins, products of Aspergillus Flavus found in the high humidity environments induce HCC in humans by causing mutations in oncogenes such as codon 249 mutation of p53 in hepatocytes. In turkey, aflatoxins are f...

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Bibliographic Details
Published in:Journal of gastrointestinal cancer 2010-09, Vol.41 (3), p.185-189
Main Authors: Özdemir, Filiz Türe, Tiftikci, Arzu, Sancak, Seda, Eren, Fatih, Tahan, Veysel, Akın, Hakan, Gündüz, Feyza, Kedrah, Ala Eldeen, Üstündağ, Yücel, Avşar, Erol, Tözün, Nurdan, Özdoğan, Osman
Format: Article
Language:English
Subjects:
Adult
Aflatoxins - adverse effects
Aged
Aged, 80 and over
Cancer Research
Carcinoma, Hepatocellular - genetics
Codon
DNA Mutational Analysis
Female
Gastroenterology
Genes, p53 - genetics
Hepatitis B, Chronic - genetics
Hepatitis C, Chronic - genetics
Humans
Internal Medicine
Liver Cirrhosis - genetics
Liver Neoplasms - genetics
Male
Medicine
Medicine & Public Health
Middle Aged
Mutation
Oncology
Original Research
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Prevalence
Radiotherapy
Turkey
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Summary:  Hepatocellular carcinoma (HCC) is one of the most common cancers in the worldwide. Aflotoxins, products of Aspergillus Flavus found in the high humidity environments induce HCC in humans by causing mutations in oncogenes such as codon 249 mutation of p53 in hepatocytes. In turkey, aflatoxins are found to be increased in some foods in certain areas, such as Istanbul which have high humidity. In present study we aimed to look for the prevalence of codon 249 mutation of p53 in patients with HCC, cirrhosis and chronic hepatitis B (CHB). Methods DNA was extracted from plasma and mutation was detected by PCR-RFLP method. Results the codon 249 mutation of p53 is found one out of 50 HCC (2%) patients. In conclusion, although codon 249 mutation of p53 gene has been found very rare but it exists showing the effect of aflatoxins in HCC patients in Turkey.
ISSN:1941-6628
1941-6636
DOI:10.1007/s12029-010-9140-5