The protective effects of ambroxol on radiation lung injury and influence on production of transforming growth factor β1 and tumor necrosis factor α

The aim of this article was to investigate the effect of ambroxol on radiation lung injury and the expression of transforming growth factor β 1 (TGF-β 1 ), as well as tumor necrosis factor α (TNF-α) in plasma. Totally, 120 patients with locally advanced lung cancer in radiotherapy were randomized in...

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Bibliographic Details
Published in:Medical oncology (Northwood, London, England) London, England), 2010-09, Vol.27 (3), p.697-701
Main Authors: Xia, De-Hong, Xi, Lei, Xv, Chen, Mao, Wei-Dong, Shen, Wei-Sheng, Shu, Zhong-Qin, Yang, Hong-Zhi, Dai, Min
Format: Article
Language:English
Subjects:
Hematology
Internal Medicine
Medicine
Medicine & Public Health
Oncology
Original Paper
Pathology
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Summary:The aim of this article was to investigate the effect of ambroxol on radiation lung injury and the expression of transforming growth factor β 1 (TGF-β 1 ), as well as tumor necrosis factor α (TNF-α) in plasma. Totally, 120 patients with locally advanced lung cancer in radiotherapy were randomized into treatment and control groups. Patients in the treatment group took ambroxol orally at a dosage of 90 mg, three times per day for 3 months from the beginning of radiotherapy. The expression of TGF-β 1 and TNF-α in plasma was analyzed. The clinical symptoms and lung diffusing capacity were monitored using high resolving power computed tomography. The level of TGF-β 1 in the control group was increased (11.8 ± 5.5 ng/ml), whereas in ambroxol-treated patients, the increase was not significant (5.6 ± 2.6 ng/ml, P  
ISSN:1357-0560
1559-131X
DOI:10.1007/s12032-009-9271-3