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The protective effects of ambroxol on radiation lung injury and influence on production of transforming growth factor β1 and tumor necrosis factor α
The aim of this article was to investigate the effect of ambroxol on radiation lung injury and the expression of transforming growth factor β 1 (TGF-β 1 ), as well as tumor necrosis factor α (TNF-α) in plasma. Totally, 120 patients with locally advanced lung cancer in radiotherapy were randomized in...
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| Published in: | Medical oncology (Northwood, London, England) London, England), 2010-09, Vol.27 (3), p.697-701 |
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| Main Authors: | , , , , , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c2033-632a87b9022c7fddeb0f14c2bac3b735f2da2da80b715df4dd18fd50ebb0d8693 |
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| cites | cdi_FETCH-LOGICAL-c2033-632a87b9022c7fddeb0f14c2bac3b735f2da2da80b715df4dd18fd50ebb0d8693 |
| container_end_page | 701 |
| container_issue | 3 |
| container_start_page | 697 |
| container_title | Medical oncology (Northwood, London, England) |
| container_volume | 27 |
| creator | Xia, De-Hong Xi, Lei Xv, Chen Mao, Wei-Dong Shen, Wei-Sheng Shu, Zhong-Qin Yang, Hong-Zhi Dai, Min |
| description | The aim of this article was to investigate the effect of ambroxol on radiation lung injury and the expression of transforming growth factor β
1
(TGF-β
1
), as well as tumor necrosis factor α (TNF-α) in plasma. Totally, 120 patients with locally advanced lung cancer in radiotherapy were randomized into treatment and control groups. Patients in the treatment group took ambroxol orally at a dosage of 90 mg, three times per day for 3 months from the beginning of radiotherapy. The expression of TGF-β
1
and TNF-α in plasma was analyzed. The clinical symptoms and lung diffusing capacity were monitored using high resolving power computed tomography. The level of TGF-β
1
in the control group was increased (11.8 ± 5.5 ng/ml), whereas in ambroxol-treated patients, the increase was not significant (5.6 ± 2.6 ng/ml,
P
|
| doi_str_mv | 10.1007/s12032-009-9271-3 |
| format | article |
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1
(TGF-β
1
), as well as tumor necrosis factor α (TNF-α) in plasma. Totally, 120 patients with locally advanced lung cancer in radiotherapy were randomized into treatment and control groups. Patients in the treatment group took ambroxol orally at a dosage of 90 mg, three times per day for 3 months from the beginning of radiotherapy. The expression of TGF-β
1
and TNF-α in plasma was analyzed. The clinical symptoms and lung diffusing capacity were monitored using high resolving power computed tomography. The level of TGF-β
1
in the control group was increased (11.8 ± 5.5 ng/ml), whereas in ambroxol-treated patients, the increase was not significant (5.6 ± 2.6 ng/ml,
P
< 0.001). Radiotherapy-induced elevation of TNF-α levels, seen in control patients, was also abolished after treatment with ambroxol (5.1 ± 1.0 vs. 2.4 ± 0.8 ng/ml,
P
< 0.001). In the treatment group, carbon monoxide diffusion capacity was not significantly decreased at 6, 12, and 18 months post-radiotherapy, compared with the control group (
P
< 0.05). Ambroxol decreased the expression of TGF-β
1
and TNF-α, and minimized the diminishment of lung diffusion capacity after radiotherapy.</description><identifier>ISSN: 1357-0560</identifier><identifier>EISSN: 1559-131X</identifier><identifier>DOI: 10.1007/s12032-009-9271-3</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Hematology ; Internal Medicine ; Medicine ; Medicine & Public Health ; Oncology ; Original Paper ; Pathology</subject><ispartof>Medical oncology (Northwood, London, England), 2010-09, Vol.27 (3), p.697-701</ispartof><rights>Humana Press Inc. 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2033-632a87b9022c7fddeb0f14c2bac3b735f2da2da80b715df4dd18fd50ebb0d8693</citedby><cites>FETCH-LOGICAL-c2033-632a87b9022c7fddeb0f14c2bac3b735f2da2da80b715df4dd18fd50ebb0d8693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Xia, De-Hong</creatorcontrib><creatorcontrib>Xi, Lei</creatorcontrib><creatorcontrib>Xv, Chen</creatorcontrib><creatorcontrib>Mao, Wei-Dong</creatorcontrib><creatorcontrib>Shen, Wei-Sheng</creatorcontrib><creatorcontrib>Shu, Zhong-Qin</creatorcontrib><creatorcontrib>Yang, Hong-Zhi</creatorcontrib><creatorcontrib>Dai, Min</creatorcontrib><title>The protective effects of ambroxol on radiation lung injury and influence on production of transforming growth factor β1 and tumor necrosis factor α</title><title>Medical oncology (Northwood, London, England)</title><addtitle>Med Oncol</addtitle><description>The aim of this article was to investigate the effect of ambroxol on radiation lung injury and the expression of transforming growth factor β
1
(TGF-β
1
), as well as tumor necrosis factor α (TNF-α) in plasma. Totally, 120 patients with locally advanced lung cancer in radiotherapy were randomized into treatment and control groups. Patients in the treatment group took ambroxol orally at a dosage of 90 mg, three times per day for 3 months from the beginning of radiotherapy. The expression of TGF-β
1
and TNF-α in plasma was analyzed. The clinical symptoms and lung diffusing capacity were monitored using high resolving power computed tomography. The level of TGF-β
1
in the control group was increased (11.8 ± 5.5 ng/ml), whereas in ambroxol-treated patients, the increase was not significant (5.6 ± 2.6 ng/ml,
P
< 0.001). Radiotherapy-induced elevation of TNF-α levels, seen in control patients, was also abolished after treatment with ambroxol (5.1 ± 1.0 vs. 2.4 ± 0.8 ng/ml,
P
< 0.001). In the treatment group, carbon monoxide diffusion capacity was not significantly decreased at 6, 12, and 18 months post-radiotherapy, compared with the control group (
P
< 0.05). Ambroxol decreased the expression of TGF-β
1
and TNF-α, and minimized the diminishment of lung diffusion capacity after radiotherapy.</description><subject>Hematology</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Pathology</subject><issn>1357-0560</issn><issn>1559-131X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp9kF1KAzEUhYMoWKsL8C0bGL1Jms7MoxT_oOBLBd9CftspM0lJZtRuxH3oQlyTaSs-CoGcS853uDkIXRK4IgDldSIUGC0A6qKmJSnYERoRzuuCMPJynDXjZQF8CqfoLKU1ACWc1iP0sVhZvImht7pvXi22zmWVcHBYdiqG99Di4HGUppF9k1U7-CVu_HqIWyy9ydK1g_Xa7mw5yAx678sBfZQ-uRC7JiPLGN76FXZS9yHi7y-yp_uhy5O3OobUpL_Xz3N04mSb7MXvPUbPd7eL2UMxf7p_nN3MC52_y4opo7IqVQ2U6tIZYxU4MtFUSc1UybijRuZTgSoJN25iDKmc4WCVAlNNazZG5JC7WyBF68QmNp2MW0FA7IoVh2JFLlbsihUsM_TApOz1SxvFOgzR5zX_gX4AuJWBhA</recordid><startdate>201009</startdate><enddate>201009</enddate><creator>Xia, De-Hong</creator><creator>Xi, Lei</creator><creator>Xv, Chen</creator><creator>Mao, Wei-Dong</creator><creator>Shen, Wei-Sheng</creator><creator>Shu, Zhong-Qin</creator><creator>Yang, Hong-Zhi</creator><creator>Dai, Min</creator><general>Springer US</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201009</creationdate><title>The protective effects of ambroxol on radiation lung injury and influence on production of transforming growth factor β1 and tumor necrosis factor α</title><author>Xia, De-Hong ; Xi, Lei ; Xv, Chen ; Mao, Wei-Dong ; Shen, Wei-Sheng ; Shu, Zhong-Qin ; Yang, Hong-Zhi ; Dai, Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2033-632a87b9022c7fddeb0f14c2bac3b735f2da2da80b715df4dd18fd50ebb0d8693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Hematology</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xia, De-Hong</creatorcontrib><creatorcontrib>Xi, Lei</creatorcontrib><creatorcontrib>Xv, Chen</creatorcontrib><creatorcontrib>Mao, Wei-Dong</creatorcontrib><creatorcontrib>Shen, Wei-Sheng</creatorcontrib><creatorcontrib>Shu, Zhong-Qin</creatorcontrib><creatorcontrib>Yang, Hong-Zhi</creatorcontrib><creatorcontrib>Dai, Min</creatorcontrib><collection>CrossRef</collection><jtitle>Medical oncology (Northwood, London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xia, De-Hong</au><au>Xi, Lei</au><au>Xv, Chen</au><au>Mao, Wei-Dong</au><au>Shen, Wei-Sheng</au><au>Shu, Zhong-Qin</au><au>Yang, Hong-Zhi</au><au>Dai, Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The protective effects of ambroxol on radiation lung injury and influence on production of transforming growth factor β1 and tumor necrosis factor α</atitle><jtitle>Medical oncology (Northwood, London, England)</jtitle><stitle>Med Oncol</stitle><date>2010-09</date><risdate>2010</risdate><volume>27</volume><issue>3</issue><spage>697</spage><epage>701</epage><pages>697-701</pages><issn>1357-0560</issn><eissn>1559-131X</eissn><abstract>The aim of this article was to investigate the effect of ambroxol on radiation lung injury and the expression of transforming growth factor β
1
(TGF-β
1
), as well as tumor necrosis factor α (TNF-α) in plasma. Totally, 120 patients with locally advanced lung cancer in radiotherapy were randomized into treatment and control groups. Patients in the treatment group took ambroxol orally at a dosage of 90 mg, three times per day for 3 months from the beginning of radiotherapy. The expression of TGF-β
1
and TNF-α in plasma was analyzed. The clinical symptoms and lung diffusing capacity were monitored using high resolving power computed tomography. The level of TGF-β
1
in the control group was increased (11.8 ± 5.5 ng/ml), whereas in ambroxol-treated patients, the increase was not significant (5.6 ± 2.6 ng/ml,
P
< 0.001). Radiotherapy-induced elevation of TNF-α levels, seen in control patients, was also abolished after treatment with ambroxol (5.1 ± 1.0 vs. 2.4 ± 0.8 ng/ml,
P
< 0.001). In the treatment group, carbon monoxide diffusion capacity was not significantly decreased at 6, 12, and 18 months post-radiotherapy, compared with the control group (
P
< 0.05). Ambroxol decreased the expression of TGF-β
1
and TNF-α, and minimized the diminishment of lung diffusion capacity after radiotherapy.</abstract><cop>Boston</cop><pub>Springer US</pub><doi>10.1007/s12032-009-9271-3</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 1357-0560 |
| ispartof | Medical oncology (Northwood, London, England), 2010-09, Vol.27 (3), p.697-701 |
| issn | 1357-0560 1559-131X |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_s12032_009_9271_3 |
| source | Springer Nature |
| subjects | Hematology Internal Medicine Medicine Medicine & Public Health Oncology Original Paper Pathology |
| title | The protective effects of ambroxol on radiation lung injury and influence on production of transforming growth factor β1 and tumor necrosis factor α |
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