Two expedient ‘one-pot’ methods for synthesis of β-aryl-β-mercaptoketones over anhydrous potassium carbonate or amberlyst-15 catalyst

Two expedient one-pot methods have been developed for synthesis of β -aryl- β -mercaptoketones using acetophenones, benzaldehydes and thiols as starting materials. The methods involve microwave irradiation (5 min) of 1:1 mixtures of acetophenones and benzaldehydes over neutral alumina supported anhy...

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Bibliographic Details
Published in:Journal of chemical sciences (Bangalore, India) India), 2013-11, Vol.125 (6), p.1463-1470
Main Authors: GUHA, CHAYAN, MONDAL, RINA, PAL, RAMMOHAN, MALLIK, ASOK K
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
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Summary:Two expedient one-pot methods have been developed for synthesis of β -aryl- β -mercaptoketones using acetophenones, benzaldehydes and thiols as starting materials. The methods involve microwave irradiation (5 min) of 1:1 mixtures of acetophenones and benzaldehydes over neutral alumina supported anhydrous potassium carbonate or amberlyst-15 in the first step, and that is followed by addition of thiol to the resulting material and keeping at room temperature for 1.5 h. Graphical Abstract Anhydrous potassium carbonate and amberlyst-15 are found to be efficient catalysts for the synthesis of β -aryl- β -mercaptoketones from acetophenones, benzaldehydes and thiols under solvent-free conditions. The experimental procedure is simple, involves shorter reaction times and results in good to excellent yield of the products.
ISSN:0974-3626
0973-7103
DOI:10.1007/s12039-013-0513-8