Facile eco-friendly synthesis of novel chromeno[4,3-b]pyridine-2,5-diones and evaluation of their antimicrobial and antioxidant properties

• Published in: Journal of chemical sciences (Bangalore, India) India), 2014, Vol.126 (1), p.187-195
• Main Authors: JAGGAVARAPU, SATYANARAYANA REDDY, KAMALAKARAN, ANAND SOLOMON, JALLI, VENTKATA PRASAD, GANGISETTY, SRAVAN KUMAR, GANESH, MUNUSSWAMY RAMANUJAM, GADDAMANUGU, GOPIKRISHNA
• Format: Article
• Language: English
• Subjects: Chemistry; Chemistry and Materials Science; Chemistry/Food Science
• ISSN: 0974-3626; 0973-7103
• DOI: 10.1007/s12039-013-0565-9

Rapid and facile access to novel chromeno[4,3-b]pyridine-2,5-dione derivatives was achieved by a mild base catalysed reaction of 4-chloro-3-formylcoumarin and acetoacetamides in PEG-300 as recyclable solvent. The compounds were evaluated for their antimicrobial activities against 3 Gram-positive and 3 Gram-negative bacteria ( Staphylococcus epidermis , Vibrio parahaemolyticus , Bacillus subtilis , Escherichia coli , Staphylococcus aureus and Klebsiella pneumonia ) with Cefotaxime control. They were further subjected to antioxidant studies using DPPH test with ascorbic acid control. While compounds 5d and 5k showed promising broad spectrum antibacterial properties against all the evaluated bacteria, compound 5g exhibited good antioxidant properties. Figure Tricyclic chromeno[4,3-b]pyridine-2,5-diones are precipitated as pure products from the reaction of 4-chloro-3-formyl-coumarin and acetoacetamides in PEG-300 as recyclable solvent and evaluated for their antimicrobial and antioxidant properties.