Synthesis and characterization of new thiourea and urea derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[d] isoxazole: In vitro Antimicrobial and Antioxidant activity

A new class of antimicrobial and antioxidant agents, based on thiourea and urea derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[ d ] isoxazole were synthesized by adopting a simple and efficient method. Synthesized compounds were characterized by spectral data of IR, 1 H, 13 C NMR and mass spectra....

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Bibliographic Details
Published in:Journal of chemical sciences (Bangalore, India) India), 2015-10, Vol.127 (10), p.1739-1746
Main Authors: SUDHAMANI, HASTI, BASHA, SK THASLIM, VENKATESWARLU, NAGAM, VIJAYA, TARTTE, RAJU, CHAMARTHI NAGA
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
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Summary:A new class of antimicrobial and antioxidant agents, based on thiourea and urea derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[ d ] isoxazole were synthesized by adopting a simple and efficient method. Synthesized compounds were characterized by spectral data of IR, 1 H, 13 C NMR and mass spectra. The compounds were evaluated for their efficacy as antimicrobial and antioxidant agents. A few compounds showed good antibacterial, antifungal and antioxidant activity when compared to standard drugs and thus represent a new class of promising lead compounds. Graphical Abstract A new series of thiourea and urea derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[ d ] isoxazole were synthesized in a convenient way. The in vitro antimicrobial activity of the title compounds were screened against selected organisms by disc diffusion technique and the antioxidant activity were evaluated by H 2 O 2 and DPPH Methods.
ISSN:0974-3626
0973-7103
DOI:10.1007/s12039-015-0935-6