Synthesis of N-acylurea derivatives from carboxylic acids and N,N′-dialkyl carbodiimides in water

Reactions of benzoic acid derivatives and ( E )-cinnamic acid derivatives with N , N ′ -dialkyl carbodiimide proceed smoothly at room temperature and in neutral conditions to afford N -acylurea derivatives in high yields. The reaction proceeds smoothly and cleanly under mild conditions and no side r...

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Published in:Journal of chemical sciences (Bangalore, India) India), 2015-12, Vol.127 (12), p.2269-2282
Main Authors: RAMAZANI, ALI, NASRABADI, FATEMEH ZEINALI, REZAEI, ARAM, ROUHANI, MORTEZA, AHANKAR, HAMIDEH, ASIABI, PEGAH AZIMZADEH, JOO, SANG WOO, ŚLEPOKURA, KATARZYNA, LIS, TADEUSZ
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
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Summary:Reactions of benzoic acid derivatives and ( E )-cinnamic acid derivatives with N , N ′ -dialkyl carbodiimide proceed smoothly at room temperature and in neutral conditions to afford N -acylurea derivatives in high yields. The reaction proceeds smoothly and cleanly under mild conditions and no side reactions were observed. Graphical Abstract Reactions of benzoic acid derivatives and ( E )-cinnamic acid derivatives with N,N ′-dialkylcarbodiimide proceed smoothly at room temperature and in neutral conditions toafford N -acylurea derivatives in high yields, and no side reactions were observed.
ISSN:0974-3626
0973-7103
DOI:10.1007/s12039-015-0988-6