Synthesis, spectral properties and DNA binding and nuclease activity of lanthanide (III) complexes of 2-benzoylpyridine benzhydrazone: X-ray crystal structure, Hirshfeld studies and nitrate-π interactions of cerium(III) complex

• Published in: Journal of chemical sciences (Bangalore, India) India), 2016, Vol.128 (1), p.23-35
• Main Authors: RAJA, KARREDDULA, SUSEELAMMA, AKKILI, REDDY, KATREDDI HUSSAIN
• Format: Article
• Language: English
• Subjects: Chemistry; Chemistry and Materials Science; Chemistry/Food Science
• ISSN: 0974-3626; 0973-7103
• DOI: 10.1007/s12039-015-1003-y

The lanthanide(III) complexes of general formula of [Ln(BPBH) 2 (NO 3 ) 3 ] (where, Ln = La, Ce, Pr, Nd and BPBH = 2-benzoylpyridine benzhydrazone) have been synthesized and characterized by elemental analysis, molar conductance, spectroscopic (UV, IR), electrochemical and single crystal X-ray diffraction studies. The coordination mode of the ligand and the geometry of [Ce(BPBH) 2 (NO 3 ) 3 ] are confirmed by single crystal X-ray studies. The crystals are monoclinic with C2/c crystallographic symmetry. The central metal is 12 coordinated and the coordination polyhedron around the cerium atom can be described as a distorted icosahedron. The existence of nitrate … π and CH … π stacking interactions in the [Ce(BPBH) 2 (NO 3 ) 3 ] leads to a supramolecular arrangement in its network. The binding properties of these complexes with calf-thymus DNA have been investigated by viscosity measurements. The complexes show more nuclease activity in the presences of H 2 O 2 . Graphical Abstract The butterfly-shaped, 12-coordinated cerium(III) complex with 2-benzoylpyridine benzhydrazone having nitrate–π supramolecular interactions shows remarkable nuclease activity in the presence of oxidant.