Wnt signalling and cancer stem cells

Intracellular signalling mediated by secreted Wnt proteins is essential for the establishment of cell fates and proper tissue patterning during embryo development and for the regulation of tissue homeostasis and stem cell function in adult tissues. Aberrant activation of Wnt signalling pathways has...

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Bibliographic Details
Published in:Clinical & translational oncology 2009-07, Vol.11 (7), p.411-427
Main Authors: Espada, Jesús, Calvo, Moisés B., Díaz-Prado, Silvia, Medina, Vanessa
Format: Article
Language:English
Subjects:
Animals
Educational Series
Humans
Medicine
Medicine & Public Health
Models, Biological
Neoplastic Stem Cells - metabolism
Oncology
Signal Transduction
Wnt Proteins - metabolism
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Summary:Intracellular signalling mediated by secreted Wnt proteins is essential for the establishment of cell fates and proper tissue patterning during embryo development and for the regulation of tissue homeostasis and stem cell function in adult tissues. Aberrant activation of Wnt signalling pathways has been directly linked to the genesis of different tumours. Here, the components and molecular mechanisms implicated in the transduction of Wnt signal, along with important results supporting a central role for this signalling pathway in stem cell function regulation and carcinogenesis will be briefly reviewed.
ISSN:1699-048X
1699-3055
DOI:10.1007/s12094-009-0380-4