Specific genetic polymorphisms of IL10-592 AA and IL10-819 TT genotypes lead to the key role for inducing docetaxel-induced liver injury in breast cancer patients

• Published in: Clinical & translational oncology 2013-04, Vol.15 (4), p.331-334
• Main Authors: Liang, Xu, Zhang, Jie, Zhu, Yulin, Lu, Yuanli, Zhou, Xinna, Wang, Zheng, Yu, Jing, Yan, Ying, Di, Lijun, Che, Li, Jiang, Hanfang, Shao, Bin, Wang, Xiaoli, Yang, Huabing, Lyerly, Herbert Kim, Ren, Jun
• Format: Article
• Language: English
• Subjects: Adult; Aged; Antineoplastic Agents - adverse effects; Antineoplastic Agents - therapeutic use; Breast Neoplasms - drug therapy; Breast Neoplasms - genetics; Brief Research Article; Case-Control Studies; Chemical and Drug Induced Liver Injury - epidemiology; Chemical and Drug Induced Liver Injury - genetics; Female; Gene Frequency; Humans; Interleukin-10 - genetics; Medicine; Medicine & Public Health; Middle Aged; Oncology; Polymorphism, Single Nucleotide - physiology; Taxoids - adverse effects; Taxoids - therapeutic use; Tumor Necrosis Factor-alpha - genetics
• ISSN: 1699-048X; 1699-3055
• DOI: 10.1007/s12094-012-0936-6

Aim This study was designed to explore the genetic polymorphism of IL-10 (−1082A/G, −592A/C, −819T/C), TNF-α (−308G/A) with susceptibility to docetaxel-induced liver injury (DILI) in Chinese breast cancer patients. Methods The targeted genetic polymorphisms of IL10-1082G/A, IL10-592A/C, IL10-819T/C, TNF-308G/A from 40 patients with DILI were assayed by matrix-assisted laser desorption/ionization-time of flight of Sequenom. Results AA genotype of IL10-592 and TT of IL10-819 significantly increased incidence of DILI ( P  = 0.005, OR = 3.137). No differences of TNF gene polymorphism between the two groups were seen. Conclusion The genetic polymorphism of the IL10-592A/C AA genotype and IL10-819T/C TT genotype was predominantly conferred to the incidence of docetaxel-induced liver injury.