Overt testicular disease at diagnosis in childhood acute lymphoblastic leukemia: prognostic significance and role of testicular irradiation

Objective To analyze the prognostic impact of overt testicular disease (OTD) at diagnosis and role of testicular irradiation in the same. Methods Data of 579 boys treated at our center over 16 years was reviewed. Results Fourteen (2.4%) males had OTD. 10 (71.4%) of these had high-risk disease. Patie...

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Bibliographic Details
Published in:Indian journal of pediatrics 2010-07, Vol.77 (7), p.779-783
Main Authors: Marwaha, Ram Kumar, Kulkarni, K. P., Bansal, D., Trehan, A.
Format: Article
Language:English
Subjects:
Adolescent
Antineoplastic Combined Chemotherapy Protocols
Biological and medical sciences
Child
Child, Preschool
General aspects
Gynecology
Hematologic and hematopoietic diseases
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Medicine
Medicine & Public Health
Methotrexate - administration & dosage
Multivariate Analysis
Neoplasm Recurrence, Local - prevention & control
Original Article
Pediatrics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - radiotherapy
Prognosis
Proportional Hazards Models
Retrospective Studies
Survival Analysis
Testicular Neoplasms - pathology
Testicular Neoplasms - radiotherapy
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Summary:Objective To analyze the prognostic impact of overt testicular disease (OTD) at diagnosis and role of testicular irradiation in the same. Methods Data of 579 boys treated at our center over 16 years was reviewed. Results Fourteen (2.4%) males had OTD. 10 (71.4%) of these had high-risk disease. Patients with OTD, had a significantly higher incidence of mediastinal-adenopathy (p=0.001), hyperleucocytosis (p=0.004) and CNS disease at presentation (p
ISSN:0019-5456
0973-7693
DOI:10.1007/s12098-010-0119-9