A Simple Approach to Preparation of Surfactant Nano-Micelles Loaded Drugs

The ability to formulate optimum drug-loaded carriers is a challenge that impedes virtuous drug delivery and stability. Nano micelles (NMs) are highly prospective carriers due to their minute dimensions and exceptional biocompatibility. This study investigated a more efficient and straightforward fa...

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Bibliographic Details
Published in:Journal of pharmaceutical innovation 2024-06, Vol.19 (3), Article 21
Main Authors: Al-lami, Mohammed S., Alshawi, Malathe A, Saker, Farouq M.
Format: Article
Language:English
Subjects:
Biochemical Engineering
Biomedical and Life Sciences
Biomedicine
Biotechnology
Industrial and Production Engineering
Original Article
Pharmacology/Toxicology
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Summary:The ability to formulate optimum drug-loaded carriers is a challenge that impedes virtuous drug delivery and stability. Nano micelles (NMs) are highly prospective carriers due to their minute dimensions and exceptional biocompatibility. This study investigated a more efficient and straightforward fabrication method for surfactant nano micelles than the conventional solvent vaporization process. The objective was to develop and validate the Direct Method, an expedited approach for producing surfactant NMs. Tween 20, was employed to simulate the solubility of various drugs in Surfactant, including azithromycin monohydrate, fusidic acid, and metronidazole. Four distinct concentrations of the medication were employed. The polydispersity index and micellar diameter were employed to compare and contrast the two methodologies. No significant differences ( p  
ISSN:1872-5120
1939-8042
DOI:10.1007/s12247-024-09827-9