Überlebenswichtig: Glutaminsynthetasehomologe Proteine in Streptomyceten

Streptomycetes have to cope with fluctuating nitrogen conditions in soil. Key enzymes in nitrogen metabolism in streptomycetes are the two glutamine synthetases (GSs), GlnA and GlnII. We demonstrated that GlnA3 and GlnA4, proteins previously annotated as GSs, are involved in utilization and detoxifi...

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Bibliographic Details
Published in:Biospektrum 2022-02, Vol.28 (1), p.23-26
Main Authors: Krysenko, Sergii, Wohlleben, Wolfgang
Format: Article
Language:ger
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Summary:Streptomycetes have to cope with fluctuating nitrogen conditions in soil. Key enzymes in nitrogen metabolism in streptomycetes are the two glutamine synthetases (GSs), GlnA and GlnII. We demonstrated that GlnA3 and GlnA4, proteins previously annotated as GSs, are involved in utilization and detoxification of polyamines and ethanolamine. Homologs of these enzymes are present in pathogenic Actinobacteria and are promising drug targets. We designed a novel strategy for development of anti-tubercular antibiotics based on the inhibition of GlnA3.
ISSN:0947-0867
1868-6249
DOI:10.1007/s12268-022-1685-x