Evaluation of oxidative stress and antioxidative action of green tea catechins in patients treated with tamoxifen: a randomized open-label, crossover study

The relation between oxidative stress and tamoxifen is not completely clear, since some studies attribute a possible antioxidant action, while others describe several pro-oxidative effects. The aim of this study was to evaluate oxidative stress in patients treated with tamoxifen and the effect of ad...

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Bibliographic Details
Published in:Mediterranean Journal of nutrition and metabolism 2011-08, Vol.4 (2), p.127-132
Main Authors: Ronzani, G., Giaretta, R., Morello, M.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Diabetes
Food Science
Metabolic Diseases
Nutrition
Oncology
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Summary:The relation between oxidative stress and tamoxifen is not completely clear, since some studies attribute a possible antioxidant action, while others describe several pro-oxidative effects. The aim of this study was to evaluate oxidative stress in patients treated with tamoxifen and the effect of administration of green tea catechins on this parameter. Tests aimed at evaluating the derivatives of reactive oxygen metabolites (d-Roms test) and the antioxidant reserve (BAP test) were adopted to estimate oxidative stress. Subjects treated with tamoxifen received Categ [Sofar] (green tea extract with 200 mg of catechins, 2 tablets twice a day for 3 weeks), according to a crossover design. High or very high antioxidant stress levels were found in all the 46 patients treated with tamoxifen, while in a control group of 18 patients treated with aromatase inhibitors or who had no longer been treated with tamoxifen for 1 year or more, high or very high oxidative stress levels were found in 66.7% of cases ( p  
ISSN:1973-798X
1973-7998
DOI:10.1007/s12349-010-0020-0