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Persistent asymptomatic isolated hematuria in children: clinical and histopathological features and prognosis
Background This study involving 351 children who had undergone kidney biopsy secondary to persistent asymptomatic isolated hematuria was undertaken to assess histological diagnosis of the disease and its natural history and prognosis. Methods The patients were divided into two groups: 215 patients w...
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| Published in: | World journal of pediatrics : WJP 2013-05, Vol.9 (2), p.163-168 |
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| Main Authors: | , , , , , , , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c344t-12c98ac10d2be73dd1f931d8d60f1dff1eb555d60d55d17612585866e1196abb3 |
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| cites | cdi_FETCH-LOGICAL-c344t-12c98ac10d2be73dd1f931d8d60f1dff1eb555d60d55d17612585866e1196abb3 |
| container_end_page | 168 |
| container_issue | 2 |
| container_start_page | 163 |
| container_title | World journal of pediatrics : WJP |
| container_volume | 9 |
| creator | Feng, Chun-Yue Xia, Yong-Hui Wang, Wen-Jin Xia, Jin Fu, Hai-Dong Wang, Xia Shen, Hui-Jun Qian, Gu-Ling Liu, Ai-Min Mao, Jian-Hua |
| description | Background
This study involving 351 children who had undergone kidney biopsy secondary to persistent asymptomatic isolated hematuria was undertaken to assess histological diagnosis of the disease and its natural history and prognosis.
Methods
The patients were divided into two groups: 215 patients with asymptomatic isolated microhematuria (AIMH; proteinuria |
| doi_str_mv | 10.1007/s12519-013-0415-3 |
| format | article |
| fullrecord | <record><control><sourceid>crossref_sprin</sourceid><recordid>TN_cdi_crossref_primary_10_1007_s12519_013_0415_3</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_1007_s12519_013_0415_3</sourcerecordid><originalsourceid>FETCH-LOGICAL-c344t-12c98ac10d2be73dd1f931d8d60f1dff1eb555d60d55d17612585866e1196abb3</originalsourceid><addsrcrecordid>eNp9UMlOwzAQtRBIlMIHcPMPGDxJ4zjcUMUmVYIDnC3HS-sqsSPbPfTvcRvOXGZ_b2YeQvdAH4DS9jFB1UBHKNSErqAh9QVaAGctoYy3lyVuKSe8Yd01uklpTymrgNEFGr9MTC5l4zOW6ThOOYwyO4VdCoPMRuOdKYVDdBI7j9XODToa_4TV4LxTcsDSl5nCECaZd2EI23PVmhPIpHN7imHrQ1lzi66sHJK5-_NL9PP68r1-J5vPt4_184aoerXKBCrVcamA6qo3ba012K4GzTWjFrS1YPqmaUqmi4WWld95wxkzAB2TfV8vEcy8KoaUorFiim6U8SiAipNeYtZLFL3ESS9RF0w1Y1KZ9VsTxT4coi9n_gP6BbEvcNk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Persistent asymptomatic isolated hematuria in children: clinical and histopathological features and prognosis</title><source>Springer Nature</source><creator>Feng, Chun-Yue ; Xia, Yong-Hui ; Wang, Wen-Jin ; Xia, Jin ; Fu, Hai-Dong ; Wang, Xia ; Shen, Hui-Jun ; Qian, Gu-Ling ; Liu, Ai-Min ; Mao, Jian-Hua</creator><creatorcontrib>Feng, Chun-Yue ; Xia, Yong-Hui ; Wang, Wen-Jin ; Xia, Jin ; Fu, Hai-Dong ; Wang, Xia ; Shen, Hui-Jun ; Qian, Gu-Ling ; Liu, Ai-Min ; Mao, Jian-Hua</creatorcontrib><description>Background
This study involving 351 children who had undergone kidney biopsy secondary to persistent asymptomatic isolated hematuria was undertaken to assess histological diagnosis of the disease and its natural history and prognosis.
Methods
The patients were divided into two groups: 215 patients with asymptomatic isolated microhematuria (AIMH; proteinuria <0.1 g/day) and 136 patients with persistent asymptomatic microhematuria, recurrent macrohematuria and/or proteinuria (AMHP; proteinuria 0.1–0.25 g/day). After kidney biopsy, the patients were monitored for 2–10 years.
Results
Normal biopsies or minor abnormalities were more frequent in AIMH patients than those in AMHP patients, who exhibited IgA nephropathy more frequently. During the 2- to 10-year follow-up period, adverse renal events (i.e., development of proteinuria, hypertension, or impaired renal function) were observed in 13/215 (6.0%) patients with AIMH and 31/136 (22.8%) patients with AMHP (χ
2
=15.521,
P
<0.001).
Conclusions
Normal biopsies or minor abnormalities were more frequently observed in AIMH patients, whereas IgA nephropathy and adverse renal events were more frequent in AMHP. Microscopic hematuria, especially when accompanied by macroscopic hematuria and proteinuria, may represent an important risk factor for the development of chronic kidney disease.</description><identifier>ISSN: 1708-8569</identifier><identifier>EISSN: 1867-0687</identifier><identifier>DOI: 10.1007/s12519-013-0415-3</identifier><language>eng</language><publisher>Heidelberg: SP Children’s Hospital, Zhejiang University School of Medicine</publisher><subject>Critical Care Medicine ; Imaging ; Intensive ; Maternal and Child Health ; Medicine ; Medicine & Public Health ; Original Article ; Pediatric Surgery ; Pediatrics ; Radiology ; Surgery</subject><ispartof>World journal of pediatrics : WJP, 2013-05, Vol.9 (2), p.163-168</ispartof><rights>Children's Hospital, Zhejiang University School of Medicine and Springer-Verlag Berlin Heidelberg 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-12c98ac10d2be73dd1f931d8d60f1dff1eb555d60d55d17612585866e1196abb3</citedby><cites>FETCH-LOGICAL-c344t-12c98ac10d2be73dd1f931d8d60f1dff1eb555d60d55d17612585866e1196abb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Feng, Chun-Yue</creatorcontrib><creatorcontrib>Xia, Yong-Hui</creatorcontrib><creatorcontrib>Wang, Wen-Jin</creatorcontrib><creatorcontrib>Xia, Jin</creatorcontrib><creatorcontrib>Fu, Hai-Dong</creatorcontrib><creatorcontrib>Wang, Xia</creatorcontrib><creatorcontrib>Shen, Hui-Jun</creatorcontrib><creatorcontrib>Qian, Gu-Ling</creatorcontrib><creatorcontrib>Liu, Ai-Min</creatorcontrib><creatorcontrib>Mao, Jian-Hua</creatorcontrib><title>Persistent asymptomatic isolated hematuria in children: clinical and histopathological features and prognosis</title><title>World journal of pediatrics : WJP</title><addtitle>World J Pediatr</addtitle><description>Background
This study involving 351 children who had undergone kidney biopsy secondary to persistent asymptomatic isolated hematuria was undertaken to assess histological diagnosis of the disease and its natural history and prognosis.
Methods
The patients were divided into two groups: 215 patients with asymptomatic isolated microhematuria (AIMH; proteinuria <0.1 g/day) and 136 patients with persistent asymptomatic microhematuria, recurrent macrohematuria and/or proteinuria (AMHP; proteinuria 0.1–0.25 g/day). After kidney biopsy, the patients were monitored for 2–10 years.
Results
Normal biopsies or minor abnormalities were more frequent in AIMH patients than those in AMHP patients, who exhibited IgA nephropathy more frequently. During the 2- to 10-year follow-up period, adverse renal events (i.e., development of proteinuria, hypertension, or impaired renal function) were observed in 13/215 (6.0%) patients with AIMH and 31/136 (22.8%) patients with AMHP (χ
2
=15.521,
P
<0.001).
Conclusions
Normal biopsies or minor abnormalities were more frequently observed in AIMH patients, whereas IgA nephropathy and adverse renal events were more frequent in AMHP. Microscopic hematuria, especially when accompanied by macroscopic hematuria and proteinuria, may represent an important risk factor for the development of chronic kidney disease.</description><subject>Critical Care Medicine</subject><subject>Imaging</subject><subject>Intensive</subject><subject>Maternal and Child Health</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Radiology</subject><subject>Surgery</subject><issn>1708-8569</issn><issn>1867-0687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9UMlOwzAQtRBIlMIHcPMPGDxJ4zjcUMUmVYIDnC3HS-sqsSPbPfTvcRvOXGZ_b2YeQvdAH4DS9jFB1UBHKNSErqAh9QVaAGctoYy3lyVuKSe8Yd01uklpTymrgNEFGr9MTC5l4zOW6ThOOYwyO4VdCoPMRuOdKYVDdBI7j9XODToa_4TV4LxTcsDSl5nCECaZd2EI23PVmhPIpHN7imHrQ1lzi66sHJK5-_NL9PP68r1-J5vPt4_184aoerXKBCrVcamA6qo3ba012K4GzTWjFrS1YPqmaUqmi4WWld95wxkzAB2TfV8vEcy8KoaUorFiim6U8SiAipNeYtZLFL3ESS9RF0w1Y1KZ9VsTxT4coi9n_gP6BbEvcNk</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Feng, Chun-Yue</creator><creator>Xia, Yong-Hui</creator><creator>Wang, Wen-Jin</creator><creator>Xia, Jin</creator><creator>Fu, Hai-Dong</creator><creator>Wang, Xia</creator><creator>Shen, Hui-Jun</creator><creator>Qian, Gu-Ling</creator><creator>Liu, Ai-Min</creator><creator>Mao, Jian-Hua</creator><general>SP Children’s Hospital, Zhejiang University School of Medicine</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20130501</creationdate><title>Persistent asymptomatic isolated hematuria in children: clinical and histopathological features and prognosis</title><author>Feng, Chun-Yue ; Xia, Yong-Hui ; Wang, Wen-Jin ; Xia, Jin ; Fu, Hai-Dong ; Wang, Xia ; Shen, Hui-Jun ; Qian, Gu-Ling ; Liu, Ai-Min ; Mao, Jian-Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-12c98ac10d2be73dd1f931d8d60f1dff1eb555d60d55d17612585866e1196abb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Critical Care Medicine</topic><topic>Imaging</topic><topic>Intensive</topic><topic>Maternal and Child Health</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Radiology</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feng, Chun-Yue</creatorcontrib><creatorcontrib>Xia, Yong-Hui</creatorcontrib><creatorcontrib>Wang, Wen-Jin</creatorcontrib><creatorcontrib>Xia, Jin</creatorcontrib><creatorcontrib>Fu, Hai-Dong</creatorcontrib><creatorcontrib>Wang, Xia</creatorcontrib><creatorcontrib>Shen, Hui-Jun</creatorcontrib><creatorcontrib>Qian, Gu-Ling</creatorcontrib><creatorcontrib>Liu, Ai-Min</creatorcontrib><creatorcontrib>Mao, Jian-Hua</creatorcontrib><collection>CrossRef</collection><jtitle>World journal of pediatrics : WJP</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feng, Chun-Yue</au><au>Xia, Yong-Hui</au><au>Wang, Wen-Jin</au><au>Xia, Jin</au><au>Fu, Hai-Dong</au><au>Wang, Xia</au><au>Shen, Hui-Jun</au><au>Qian, Gu-Ling</au><au>Liu, Ai-Min</au><au>Mao, Jian-Hua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Persistent asymptomatic isolated hematuria in children: clinical and histopathological features and prognosis</atitle><jtitle>World journal of pediatrics : WJP</jtitle><stitle>World J Pediatr</stitle><date>2013-05-01</date><risdate>2013</risdate><volume>9</volume><issue>2</issue><spage>163</spage><epage>168</epage><pages>163-168</pages><issn>1708-8569</issn><eissn>1867-0687</eissn><abstract>Background
This study involving 351 children who had undergone kidney biopsy secondary to persistent asymptomatic isolated hematuria was undertaken to assess histological diagnosis of the disease and its natural history and prognosis.
Methods
The patients were divided into two groups: 215 patients with asymptomatic isolated microhematuria (AIMH; proteinuria <0.1 g/day) and 136 patients with persistent asymptomatic microhematuria, recurrent macrohematuria and/or proteinuria (AMHP; proteinuria 0.1–0.25 g/day). After kidney biopsy, the patients were monitored for 2–10 years.
Results
Normal biopsies or minor abnormalities were more frequent in AIMH patients than those in AMHP patients, who exhibited IgA nephropathy more frequently. During the 2- to 10-year follow-up period, adverse renal events (i.e., development of proteinuria, hypertension, or impaired renal function) were observed in 13/215 (6.0%) patients with AIMH and 31/136 (22.8%) patients with AMHP (χ
2
=15.521,
P
<0.001).
Conclusions
Normal biopsies or minor abnormalities were more frequently observed in AIMH patients, whereas IgA nephropathy and adverse renal events were more frequent in AMHP. Microscopic hematuria, especially when accompanied by macroscopic hematuria and proteinuria, may represent an important risk factor for the development of chronic kidney disease.</abstract><cop>Heidelberg</cop><pub>SP Children’s Hospital, Zhejiang University School of Medicine</pub><doi>10.1007/s12519-013-0415-3</doi><tpages>6</tpages></addata></record> |
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| ispartof | World journal of pediatrics : WJP, 2013-05, Vol.9 (2), p.163-168 |
| issn | 1708-8569 1867-0687 |
| language | eng |
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| source | Springer Nature |
| subjects | Critical Care Medicine Imaging Intensive Maternal and Child Health Medicine Medicine & Public Health Original Article Pediatric Surgery Pediatrics Radiology Surgery |
| title | Persistent asymptomatic isolated hematuria in children: clinical and histopathological features and prognosis |
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