Association of Long-Term Dynamics in Circulating Testosterone with Serum PSA in Prostate Cancer-Free Men with Initial-PSA < 4 ng/mL

We previously reported that an accelerated decline in circulating testosterone level is associated with a higher risk of prostate cancer (PCa). This study is to examine whether testosterone change rate is related to serum prostate-specific antigen (PSA) concentration among PCa-free men. Longitudinal...

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Bibliographic Details
Published in:Discover. Oncology 2019-12, Vol.10 (4-6), p.168-176
Main Authors: Wang, Kai, Chen, Xinguang, Cheng, Ting-Yuan David, Qiu, Peihua, Bird, Victoria Y., Prosperi, Mattia
Format: Article
Language:English
Subjects:
Aged
Aging
Aging - blood
Body mass index
Cell Biology
Cross-Sectional Studies
Diabetes
Electronic Health Records
Endocrinology
Family medical history
Humans
Internal Medicine
Longitudinal Studies
Male
Medical records
Medicine
Medicine & Public Health
Microbiology
Middle Aged
Oncology
Original Paper
Prostate cancer
Prostate-Specific Antigen - blood
Systems Biology
Tertiary Care Centers
Testosterone
Testosterone - blood
Variables
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Summary:We previously reported that an accelerated decline in circulating testosterone level is associated with a higher risk of prostate cancer (PCa). This study is to examine whether testosterone change rate is related to serum prostate-specific antigen (PSA) concentration among PCa-free men. Longitudinal data were derived from electronic medical records at a tertiary hospital in the Southeastern USA. PCa-free men with initial-PSA
ISSN:1868-8497
1868-8500
2730-6011
DOI:10.1007/s12672-019-00369-y