Hypoglycemic and hepatoprotective activity of Rosmarinus officinalis extract in diabetic rats

The present study examined the effect of water extract (200 mg/kg body weight) of Rosmarinus officinalis L. in streptozotocin (STZ)-induced diabetic rats for 21 days. The hepatoprotective effects were investigated in the liver tissues sections. There was a significant increase in serum liver biochem...

Full description

Saved in:
Bibliographic Details
Published in:Journal of physiology and biochemistry 2013-12, Vol.69 (4), p.779-783
Main Authors: Ramadan, Kholoud S., Khalil, Olfat A., Danial, Enas N., Alnahdi, Hanan S., Ayaz, Najla O.
Format: Article
Language:English
Subjects:
Alanine Transaminase - metabolism
Alkaline Phosphatase - metabolism
Animal Physiology
Animals
Aspartate Aminotransferases - metabolism
Biomedical and Life Sciences
Biomedicine
C-Peptide - metabolism
Diabetes Mellitus, Experimental - drug therapy
Diabetes Mellitus, Experimental - enzymology
Diabetes Mellitus, Experimental - pathology
Dose-Response Relationship, Drug
Human Physiology
Hypoglycemic Agents - isolation & purification
Hypoglycemic Agents - pharmacology
Insulin - blood
Liver - drug effects
Liver - enzymology
Liver - pathology
Male
Original Paper
Phytotherapy
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Rats
Rosmarinus - chemistry
Streptozocin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The present study examined the effect of water extract (200 mg/kg body weight) of Rosmarinus officinalis L. in streptozotocin (STZ)-induced diabetic rats for 21 days. The hepatoprotective effects were investigated in the liver tissues sections. There was a significant increase in serum liver biochemical parameters (aspartate aminotransferase, alanine transaminase, and alkaline phosphatase), accompanied by a significant decrease in the level of total protein and albumin in the STZ-induced rats when compared with that of the normal group. The high-dose treatment group (200 mg/kg body wt) significantly restored the elevated liver function enzymes near to normal. This study revealed that rosemary extracts exerted a hepatoprotective effect. The results indicate that the extract exhibits the protective effect on tissues and prove its potentials as an antidiabetic agent.
ISSN:1138-7548
1877-8755
DOI:10.1007/s13105-013-0253-8