Bone remodelling is reduced by recovery from iron-deficiency anaemia in premenopausal women

Iron-deficiency anaemia (IDA), one of the most common and widespread health disorders worldwide, affects fundamental metabolic functions and has been associated with deleterious effects on bone. Our aim was to know whether there are differences in bone remodelling between a group of premenopausal ID...

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Bibliographic Details
Published in:Journal of physiology and biochemistry 2013-12, Vol.69 (4), p.889-896
Main Authors: Wright, Ione, Blanco-Rojo, Ruth, Fernández, M. Cristina, Toxqui, Laura, Moreno, Gemma, Pérez-Granados, Ana M., de la Piedra, Concepción, Remacha, Ángel F., Vaquero, M. Pilar
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anemia, Iron-Deficiency - blood
Anemia, Iron-Deficiency - drug therapy
Anemia, Iron-Deficiency - pathology
Anemia, Iron-Deficiency - urine
Animal Physiology
Biomarkers - blood
Biomarkers - urine
Biomedical and Life Sciences
Biomedicine
Bone Resorption - blood
Bone Resorption - drug therapy
Bone Resorption - pathology
Bone Resorption - urine
Case-Control Studies
Collagen Type I - urine
Female
Ferrous Compounds - therapeutic use
Hematinics - therapeutic use
Human Physiology
Humans
Iron - metabolism
Original Paper
Parathyroid Hormone - blood
Peptide Fragments - blood
Peptides - urine
Premenopause
Procollagen - blood
Vitamin D - analogs & derivatives
Vitamin D - blood
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Summary:Iron-deficiency anaemia (IDA), one of the most common and widespread health disorders worldwide, affects fundamental metabolic functions and has been associated with deleterious effects on bone. Our aim was to know whether there are differences in bone remodelling between a group of premenopausal IDA women and a healthy group, and whether recovery of iron status has an effect on bone turnover markers. Thirty-five IDA women and 38 healthy women (control group) were recruited throughout the year. IDA women received pharmacological iron treatment. Iron biomarkers, aminoterminal telopeptide of collagen I (NTx), procollagen type 1 N-terminal propeptide (P1NP), 25-hydroxyvitamin D, and parathormone (PTH) were determined at baseline for both groups and after treatment with pharmacological iron for the IDA group. IDA subjects were classified as recovered (R) or non-recovered (nR) from IDA after treatment. NTx levels were significantly higher ( p
ISSN:1138-7548
1877-8755
DOI:10.1007/s13105-013-0266-3