Ferric Uptake Regulator (FUR) protein: properties and implications in cyanobacteria

The Ferric uptake regulator (Fur) protein is a global iron regulator found in most prokaryotes. Although the Fur protein is involved in a variety of metabolic pathways, it is specifically known for the regulation of several iron responsive genes. It binds to the highly conserved sequences located in...

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Bibliographic Details
Published in:Annals of microbiology 2016-03, Vol.66 (1), p.61-75
Main Authors: Kaushik, Manish Singh, Singh, Prashant, Tiwari, Balkrishna, Mishra, Arun Kumar
Format: Article
Language:English
Subjects:
Applied Microbiology
biochemical pathways
Biomedical and Life Sciences
conserved sequences
Cyanobacteria
genes
Life Sciences
mechanism of action
Medical Microbiology
Microbial Ecology
Microbial Genetics and Genomics
Microbiology
Mycology
prokaryotic cells
promoter regions
Review Article
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Summary:The Ferric uptake regulator (Fur) protein is a global iron regulator found in most prokaryotes. Although the Fur protein is involved in a variety of metabolic pathways, it is specifically known for the regulation of several iron responsive genes. It binds to the highly conserved sequences located in the upstream promoter region known as iron boxes, using ferrous ion as a co-repressor. Apart from that, the Fur protein is also directly/indirectly involved in a variety of other crucial physiological pathways. Hence, understanding the mechanism of action and the mechanistic pathways of iron regulation by Fur is necessary and important. The basic understanding of the functioning and properties of Fur protein along with its role, interaction and regulation at various levels in cyanobacteria has been discussed in detail.
ISSN:1590-4261
1869-2044
DOI:10.1007/s13213-015-1134-x