Therapeutic Response to Sublingual Methylcobalamin in Children With Vitamin B12 Deficiency Anemia

Objective To evaluate the efficacy and safety of sublingual methylcobalamin for the treatment of vitamin B12 deficiency anemia in children. Methods A single arm intervention study was conducted between November, 2020 and April, 2022 in children aged 1–12 years with vitamin B12 deficiency anemia. Chi...

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Bibliographic Details
Published in:Indian pediatrics 2023-11, Vol.60 (11), p.913-916
Main Authors: Saxena, Chahat, Kumari, Sweta, Dewan, Pooja, Gomber, Sunil, Agarwal, Rachna, Sharma, Sangeeta, Radhakrishnan, Nita, Maji, Manideepa
Format: Article
Language:English
Subjects:
Maternal and Child Health
Medicine
Medicine & Public Health
Pediatric Surgery
Pediatrics
Research Paper
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Summary:Objective To evaluate the efficacy and safety of sublingual methylcobalamin for the treatment of vitamin B12 deficiency anemia in children. Methods A single arm intervention study was conducted between November, 2020 and April, 2022 in children aged 1–12 years with vitamin B12 deficiency anemia. Children aged 1–6 years received a tablet of methylcobalamin (1500 mcg) by sublingual route every alternate day (three doses) while those aged 7–12 years received five such doses. Thereafter, one such sublingual tablet was given weekly and all participants were followed-up for 6 weeks. Results 37 children with a mean (SD) age of 8.2 (4.1) years were treated and followed-up. On day 10, no child needed rescue therapy with parenteral methylcobalamin. After 6 weeks, the mean (SD) serum cobalamin increased from 123.3 (35.5) pg/mL to 507.3 (274.2) pg/mL ( P
ISSN:0019-6061
0974-7559
DOI:10.1007/s13312-023-3035-6