Therapeutic Response to Sublingual Methylcobalamin in Children With Vitamin B12 Deficiency Anemia

Objective To evaluate the efficacy and safety of sublingual methylcobalamin for the treatment of vitamin B12 deficiency anemia in children. Methods A single arm intervention study was conducted between November, 2020 and April, 2022 in children aged 1–12 years with vitamin B12 deficiency anemia. Chi...

Full description

Saved in:
Bibliographic Details
Published in:Indian pediatrics 2023-11, Vol.60 (11), p.913-916
Main Authors: Saxena, Chahat, Kumari, Sweta, Dewan, Pooja, Gomber, Sunil, Agarwal, Rachna, Sharma, Sangeeta, Radhakrishnan, Nita, Maji, Manideepa
Format: Article
Language:English
Subjects:
Maternal and Child Health
Medicine
Medicine & Public Health
Pediatric Surgery
Pediatrics
Research Paper
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c311t-464b9c24775efd72a864bd0423fb1d9f514912089a654a907845f9879e6331c63
cites cdi_FETCH-LOGICAL-c311t-464b9c24775efd72a864bd0423fb1d9f514912089a654a907845f9879e6331c63
container_end_page 916
container_issue 11
container_start_page 913
container_title Indian pediatrics
container_volume 60
creator Saxena, Chahat
Kumari, Sweta
Dewan, Pooja
Gomber, Sunil
Agarwal, Rachna
Sharma, Sangeeta
Radhakrishnan, Nita
Maji, Manideepa
description Objective To evaluate the efficacy and safety of sublingual methylcobalamin for the treatment of vitamin B12 deficiency anemia in children. Methods A single arm intervention study was conducted between November, 2020 and April, 2022 in children aged 1–12 years with vitamin B12 deficiency anemia. Children aged 1–6 years received a tablet of methylcobalamin (1500 mcg) by sublingual route every alternate day (three doses) while those aged 7–12 years received five such doses. Thereafter, one such sublingual tablet was given weekly and all participants were followed-up for 6 weeks. Results 37 children with a mean (SD) age of 8.2 (4.1) years were treated and followed-up. On day 10, no child needed rescue therapy with parenteral methylcobalamin. After 6 weeks, the mean (SD) serum cobalamin increased from 123.3 (35.5) pg/mL to 507.3 (274.2) pg/mL ( P
doi_str_mv 10.1007/s13312-023-3035-6
format article
fullrecord <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1007_s13312_023_3035_6</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>37260065</sourcerecordid><originalsourceid>FETCH-LOGICAL-c311t-464b9c24775efd72a864bd0423fb1d9f514912089a654a907845f9879e6331c63</originalsourceid><addsrcrecordid>eNp9kN1KxDAQhYMo7rr6AN5IXqCanyZpLtf1FxRBV70MaZtus7RpSdqLfXuzVr0UBmaYOefAfACcY3SJERJXAVOKSYIITSiiLOEHYI6kSBPBmDyMM8Iy4YjjGTgJYYuikDB8DGZUEI4QZ3Og17XxujfjYAv4akLfuWDg0MG3MW-s24y6gc9mqHdN0eW60a11MNaqtk3pjYOfdqjhhx2-D9eYwBtT2cIaV-zg0pnW6lNwVOkmmLOfvgDvd7fr1UPy9HL_uFo-JQXFeEhSnuayIKkQzFSlIDqLixKlhFY5LmXFcCoxQZnUnKVaIpGlrJKZkIZHCAWnC4Cn3MJ3IXhTqd7bVvudwkjtcakJl4oU1B6X2nsuJk8_5q0p_xy_fKKATIIQT25jvNp2o3fxj39SvwDLonRv</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Therapeutic Response to Sublingual Methylcobalamin in Children With Vitamin B12 Deficiency Anemia</title><source>Springer Link</source><source>Alma/SFX Local Collection</source><creator>Saxena, Chahat ; Kumari, Sweta ; Dewan, Pooja ; Gomber, Sunil ; Agarwal, Rachna ; Sharma, Sangeeta ; Radhakrishnan, Nita ; Maji, Manideepa</creator><creatorcontrib>Saxena, Chahat ; Kumari, Sweta ; Dewan, Pooja ; Gomber, Sunil ; Agarwal, Rachna ; Sharma, Sangeeta ; Radhakrishnan, Nita ; Maji, Manideepa</creatorcontrib><description>Objective To evaluate the efficacy and safety of sublingual methylcobalamin for the treatment of vitamin B12 deficiency anemia in children. Methods A single arm intervention study was conducted between November, 2020 and April, 2022 in children aged 1–12 years with vitamin B12 deficiency anemia. Children aged 1–6 years received a tablet of methylcobalamin (1500 mcg) by sublingual route every alternate day (three doses) while those aged 7–12 years received five such doses. Thereafter, one such sublingual tablet was given weekly and all participants were followed-up for 6 weeks. Results 37 children with a mean (SD) age of 8.2 (4.1) years were treated and followed-up. On day 10, no child needed rescue therapy with parenteral methylcobalamin. After 6 weeks, the mean (SD) serum cobalamin increased from 123.3 (35.5) pg/mL to 507.3 (274.2) pg/mL ( P &lt;0.001), plasma homocysteine decreased from 48.9 (17.8) µmol/L to 16.3 (8.5) µmol/L ( P &lt;0.001), the mean (SD) hemoglobin increased by 2.3 (1.1) g/dL ( P &lt;0.001), and MCV decreased by 12.9 (6.8) fL ( P &lt;0.001). 67.6% children persisted to have anemia, albeit majority of them had mild or moderate anemia. There were no unsolicited side-effects reported. Conclusion Sublingual methylcobalamin is effective for the treatment of vitamin B12 deficiency anemia in children; although, the duration of treatment needs to be longer than six weeks.</description><identifier>ISSN: 0019-6061</identifier><identifier>EISSN: 0974-7559</identifier><identifier>DOI: 10.1007/s13312-023-3035-6</identifier><identifier>PMID: 37260065</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Maternal and Child Health ; Medicine ; Medicine &amp; Public Health ; Pediatric Surgery ; Pediatrics ; Research Paper</subject><ispartof>Indian pediatrics, 2023-11, Vol.60 (11), p.913-916</ispartof><rights>Indian Academy of Pediatrics 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-464b9c24775efd72a864bd0423fb1d9f514912089a654a907845f9879e6331c63</citedby><cites>FETCH-LOGICAL-c311t-464b9c24775efd72a864bd0423fb1d9f514912089a654a907845f9879e6331c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37260065$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saxena, Chahat</creatorcontrib><creatorcontrib>Kumari, Sweta</creatorcontrib><creatorcontrib>Dewan, Pooja</creatorcontrib><creatorcontrib>Gomber, Sunil</creatorcontrib><creatorcontrib>Agarwal, Rachna</creatorcontrib><creatorcontrib>Sharma, Sangeeta</creatorcontrib><creatorcontrib>Radhakrishnan, Nita</creatorcontrib><creatorcontrib>Maji, Manideepa</creatorcontrib><title>Therapeutic Response to Sublingual Methylcobalamin in Children With Vitamin B12 Deficiency Anemia</title><title>Indian pediatrics</title><addtitle>Indian Pediatr</addtitle><addtitle>Indian Pediatr</addtitle><description>Objective To evaluate the efficacy and safety of sublingual methylcobalamin for the treatment of vitamin B12 deficiency anemia in children. Methods A single arm intervention study was conducted between November, 2020 and April, 2022 in children aged 1–12 years with vitamin B12 deficiency anemia. Children aged 1–6 years received a tablet of methylcobalamin (1500 mcg) by sublingual route every alternate day (three doses) while those aged 7–12 years received five such doses. Thereafter, one such sublingual tablet was given weekly and all participants were followed-up for 6 weeks. Results 37 children with a mean (SD) age of 8.2 (4.1) years were treated and followed-up. On day 10, no child needed rescue therapy with parenteral methylcobalamin. After 6 weeks, the mean (SD) serum cobalamin increased from 123.3 (35.5) pg/mL to 507.3 (274.2) pg/mL ( P &lt;0.001), plasma homocysteine decreased from 48.9 (17.8) µmol/L to 16.3 (8.5) µmol/L ( P &lt;0.001), the mean (SD) hemoglobin increased by 2.3 (1.1) g/dL ( P &lt;0.001), and MCV decreased by 12.9 (6.8) fL ( P &lt;0.001). 67.6% children persisted to have anemia, albeit majority of them had mild or moderate anemia. There were no unsolicited side-effects reported. Conclusion Sublingual methylcobalamin is effective for the treatment of vitamin B12 deficiency anemia in children; although, the duration of treatment needs to be longer than six weeks.</description><subject>Maternal and Child Health</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Research Paper</subject><issn>0019-6061</issn><issn>0974-7559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kN1KxDAQhYMo7rr6AN5IXqCanyZpLtf1FxRBV70MaZtus7RpSdqLfXuzVr0UBmaYOefAfACcY3SJERJXAVOKSYIITSiiLOEHYI6kSBPBmDyMM8Iy4YjjGTgJYYuikDB8DGZUEI4QZ3Og17XxujfjYAv4akLfuWDg0MG3MW-s24y6gc9mqHdN0eW60a11MNaqtk3pjYOfdqjhhx2-D9eYwBtT2cIaV-zg0pnW6lNwVOkmmLOfvgDvd7fr1UPy9HL_uFo-JQXFeEhSnuayIKkQzFSlIDqLixKlhFY5LmXFcCoxQZnUnKVaIpGlrJKZkIZHCAWnC4Cn3MJ3IXhTqd7bVvudwkjtcakJl4oU1B6X2nsuJk8_5q0p_xy_fKKATIIQT25jvNp2o3fxj39SvwDLonRv</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Saxena, Chahat</creator><creator>Kumari, Sweta</creator><creator>Dewan, Pooja</creator><creator>Gomber, Sunil</creator><creator>Agarwal, Rachna</creator><creator>Sharma, Sangeeta</creator><creator>Radhakrishnan, Nita</creator><creator>Maji, Manideepa</creator><general>Springer India</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20231101</creationdate><title>Therapeutic Response to Sublingual Methylcobalamin in Children With Vitamin B12 Deficiency Anemia</title><author>Saxena, Chahat ; Kumari, Sweta ; Dewan, Pooja ; Gomber, Sunil ; Agarwal, Rachna ; Sharma, Sangeeta ; Radhakrishnan, Nita ; Maji, Manideepa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-464b9c24775efd72a864bd0423fb1d9f514912089a654a907845f9879e6331c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Maternal and Child Health</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Research Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saxena, Chahat</creatorcontrib><creatorcontrib>Kumari, Sweta</creatorcontrib><creatorcontrib>Dewan, Pooja</creatorcontrib><creatorcontrib>Gomber, Sunil</creatorcontrib><creatorcontrib>Agarwal, Rachna</creatorcontrib><creatorcontrib>Sharma, Sangeeta</creatorcontrib><creatorcontrib>Radhakrishnan, Nita</creatorcontrib><creatorcontrib>Maji, Manideepa</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Indian pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saxena, Chahat</au><au>Kumari, Sweta</au><au>Dewan, Pooja</au><au>Gomber, Sunil</au><au>Agarwal, Rachna</au><au>Sharma, Sangeeta</au><au>Radhakrishnan, Nita</au><au>Maji, Manideepa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic Response to Sublingual Methylcobalamin in Children With Vitamin B12 Deficiency Anemia</atitle><jtitle>Indian pediatrics</jtitle><stitle>Indian Pediatr</stitle><addtitle>Indian Pediatr</addtitle><date>2023-11-01</date><risdate>2023</risdate><volume>60</volume><issue>11</issue><spage>913</spage><epage>916</epage><pages>913-916</pages><issn>0019-6061</issn><eissn>0974-7559</eissn><abstract>Objective To evaluate the efficacy and safety of sublingual methylcobalamin for the treatment of vitamin B12 deficiency anemia in children. Methods A single arm intervention study was conducted between November, 2020 and April, 2022 in children aged 1–12 years with vitamin B12 deficiency anemia. Children aged 1–6 years received a tablet of methylcobalamin (1500 mcg) by sublingual route every alternate day (three doses) while those aged 7–12 years received five such doses. Thereafter, one such sublingual tablet was given weekly and all participants were followed-up for 6 weeks. Results 37 children with a mean (SD) age of 8.2 (4.1) years were treated and followed-up. On day 10, no child needed rescue therapy with parenteral methylcobalamin. After 6 weeks, the mean (SD) serum cobalamin increased from 123.3 (35.5) pg/mL to 507.3 (274.2) pg/mL ( P &lt;0.001), plasma homocysteine decreased from 48.9 (17.8) µmol/L to 16.3 (8.5) µmol/L ( P &lt;0.001), the mean (SD) hemoglobin increased by 2.3 (1.1) g/dL ( P &lt;0.001), and MCV decreased by 12.9 (6.8) fL ( P &lt;0.001). 67.6% children persisted to have anemia, albeit majority of them had mild or moderate anemia. There were no unsolicited side-effects reported. Conclusion Sublingual methylcobalamin is effective for the treatment of vitamin B12 deficiency anemia in children; although, the duration of treatment needs to be longer than six weeks.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>37260065</pmid><doi>10.1007/s13312-023-3035-6</doi><tpages>4</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0019-6061
ispartof Indian pediatrics, 2023-11, Vol.60 (11), p.913-916
issn 0019-6061
0974-7559
language eng
recordid cdi_crossref_primary_10_1007_s13312_023_3035_6
source Springer Link; Alma/SFX Local Collection
subjects Maternal and Child Health
Medicine
Medicine & Public Health
Pediatric Surgery
Pediatrics
Research Paper
title Therapeutic Response to Sublingual Methylcobalamin in Children With Vitamin B12 Deficiency Anemia
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T13%3A01%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Therapeutic%20Response%20to%20Sublingual%20Methylcobalamin%20in%20Children%20With%20Vitamin%20B12%20Deficiency%20Anemia&rft.jtitle=Indian%20pediatrics&rft.au=Saxena,%20Chahat&rft.date=2023-11-01&rft.volume=60&rft.issue=11&rft.spage=913&rft.epage=916&rft.pages=913-916&rft.issn=0019-6061&rft.eissn=0974-7559&rft_id=info:doi/10.1007/s13312-023-3035-6&rft_dat=%3Cpubmed_cross%3E37260065%3C/pubmed_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c311t-464b9c24775efd72a864bd0423fb1d9f514912089a654a907845f9879e6331c63%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/37260065&rfr_iscdi=true