The influence of Nifadin®, Niprisan® and Niprd/92/001/1-1 (AM-1) on the pharmacokinetics of metronidazole in rats

The single oral dose pharmacokinetics of metronidazole was studied alone and after co-administration with phytomedicines, Nifadin ® , Niprisan ® and Niprd/92/001/1-1 (AM-1), in rats. Plasma metronidazole concentrations were measured using high-performance liquid chromatography method developed earli...

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Bibliographic Details
Published in:European journal of drug metabolism and pharmacokinetics 2010-09, Vol.35 (1-2), p.55-58
Main Authors: Bakare-Odunola, M. T., Mustapha, K. B., Garba, M., Obodozie, O. O., Enemali, I. S.
Format: Article
Language:English
Subjects:
Animals
Anti-Infective Agents - pharmacokinetics
Antimalarials - pharmacology
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Herb-Drug Interactions
Human Physiology
Male
Medical Biochemistry
Medical sciences
Metronidazole - pharmacokinetics
Original Paper
Pharmaceutical Sciences/Technology
Pharmacology. Drug treatments
Pharmacology/Toxicology
Pharmacy
Plant Extracts - pharmacology
Rats
Rats, Wistar
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Summary:The single oral dose pharmacokinetics of metronidazole was studied alone and after co-administration with phytomedicines, Nifadin ® , Niprisan ® and Niprd/92/001/1-1 (AM-1), in rats. Plasma metronidazole concentrations were measured using high-performance liquid chromatography method developed earlier in our laboratory. The data were fitted into a WinNonlin standard non-compartmental programme. The co-administration of the herbal medicines with metronidazole produced an increase in the serum concentration of metronidazole at each sampling time. The highest increase of 184% occurring at the time of peak concentration (1 h) was obtained with AM-1, followed by 145% with Niprisan ® , the least was 131% with Nifadin ® . Significant increase was also observed in some other parameters, such as area under the serum concentration–time curve (AUC 0–24 ) and maximum serum concentration ( C max ), while the apparent volume of distribution ( V d ) and plasma clearance (Cl) reduced significantly ( P  
ISSN:0378-7966
2107-0180
DOI:10.1007/s13318-010-0008-7