Effect of dose and dosage interval on the oral bioavailability of docetaxel in combination with a curcumin self-emulsifying drug delivery system (SEDDS)

The present study investigated the effects of a curcumin self-emulsifying drug delivery systems (SEDDS) on the pharmacokinetics of orally administered docetaxel in rats. A single dose of docetaxel was orally administered (30 mg/kg) alone or after oral curcumin SEDDS (25, 50, 100 and 150 mg/kg) admin...

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Bibliographic Details
Published in:European journal of drug metabolism and pharmacokinetics 2012-09, Vol.37 (3), p.217-224
Main Authors: Yan, Yi-Dong, Marasini, Nirmal, Choi, Young Keun, Kim, Jong Oh, Woo, Jong Soo, Yong, Chul Soon, Choi, Han Gon
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Antineoplastic Agents - pharmacokinetics
Area Under Curve
Biological and medical sciences
Biological Availability
Biomedical and Life Sciences
Biomedicine
Curcumin - administration & dosage
Drug Delivery Systems
Emulsions
Human Physiology
Male
Medical Biochemistry
Medical sciences
Original Paper
Pharmaceutical Sciences/Technology
Pharmacology. Drug treatments
Pharmacology/Toxicology
Pharmacy
Rats
Rats, Sprague-Dawley
Taxoids - administration & dosage
Taxoids - pharmacokinetics
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Summary:The present study investigated the effects of a curcumin self-emulsifying drug delivery systems (SEDDS) on the pharmacokinetics of orally administered docetaxel in rats. A single dose of docetaxel was orally administered (30 mg/kg) alone or after oral curcumin SEDDS (25, 50, 100 and 150 mg/kg) administration with time intervals of 0, 15 and 30 min, respectively. After oral administration, the C max and the area under the plasma concentration-time curve (AUC) of docetaxel were significantly increased (0 min, p  
ISSN:0378-7966
2107-0180
DOI:10.1007/s13318-011-0078-1