Pharmacokinetic drug interactions between apigenin, rutin and paclitaxel mediated by P-glycoprotein in rats

The aim of present study was to investigate the effects of apigenin and rutin on the pharmacokinetics of paclitaxel after oral administration of paclitaxel with apigenin and rutin to rats. Paclitaxel (40 mg/kg) was administered orally alone and in combination with apigenin and rutin (10, 20, and 40 ...

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Bibliographic Details
Published in:European journal of drug metabolism and pharmacokinetics 2015-09, Vol.40 (3), p.267-276
Main Authors: Kumar, K. Kishore, Priyanka, Leena, Gnananath, K., Babu, P. Ravindra, Sujatha, S.
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Apigenin - metabolism
Area Under Curve
ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism
Biological Availability
Biomedical and Life Sciences
Biomedicine
Cytochrome P-450 CYP3A - metabolism
Drug Interactions - physiology
Half-Life
Human Physiology
Male
Medical Biochemistry
Original Paper
Paclitaxel - metabolism
Pharmaceutical Sciences/Technology
Pharmacology/Toxicology
Pharmacy
Rats
Rats, Wistar
Rutin - metabolism
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Summary:The aim of present study was to investigate the effects of apigenin and rutin on the pharmacokinetics of paclitaxel after oral administration of paclitaxel with apigenin and rutin to rats. Paclitaxel (40 mg/kg) was administered orally alone and in combination with apigenin and rutin (10, 20, and 40 mg/kg) for 15 consecutive days. In the single-dose pharmacokinetic study (SDS), blood samples were collected on 1st day whereas on 15th day in the multiple-dose pharmacokinetic study (MDS). The plasma concentrations of paclitaxel were increased dose-dependently in the combination of apigenin and rutin compared to that of paclitaxel control in SDS and MDS ( p  
ISSN:0378-7966
2107-0180
DOI:10.1007/s13318-014-0203-z