Zein-based nanocarriers for the oral delivery of insulin. In vivo evaluation in Caenorhabditis elegans

The aim was to evaluate the potential of nanocarriers, based on the coating of zein nanoparticles (ZNP) with a Gantrez® AN-PEG conjugate (GP), for the oral delivery of insulin. ZNP-GP displayed less negative surface charge and a 14-fold higher diffusion coefficient in pig intestinal mucus than ZNP....

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Bibliographic Details
Published in:Drug delivery and translational research 2021-04, Vol.11 (2), p.647-658
Main Authors: Martínez-López, Ana L., González-Navarro, Carlos J., Vizmanos, José L., Irache, Juan M.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Original Article
Pharmaceutical Sciences/Technology
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Summary:The aim was to evaluate the potential of nanocarriers, based on the coating of zein nanoparticles (ZNP) with a Gantrez® AN-PEG conjugate (GP), for the oral delivery of insulin. ZNP-GP displayed less negative surface charge and a 14-fold higher diffusion coefficient in pig intestinal mucus than ZNP. Both nanoparticles showed a spherical shape and an insulin load of 77.5 µg/mg. Under simulated gastric conditions, ZNP-GP released significantly lower amount of insulin than ZNP, while under simulated intestinal conditions, both types of nanoparticles displayed similar behaviour. In Caenorhabditis elegans wild-type N2, grown under high glucose conditions, insulin treatments reduced glucose and fat accumulation without altering the growth rate, the worm length, or the pumping rate. The effect was significantly greater ( p  
ISSN:2190-393X
2190-3948
DOI:10.1007/s13346-021-00919-4