Endogenous insulin secretion ability in meal tolerance test correlated with body mass index (BMI) in Japanese type 2 diabetes patients

Several studies report that endogenous insulin secretion (EIS) ability is correlated with BMI in glucagon stimulation tests (GST). Despite a standard method to assess EIS, GST can produce side effects such as nausea. Therefore, we investigated the relationship between EIS and BMI with a simple meal...

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Published in:International journal of diabetes in developing countries 2014-12, Vol.34 (4), p.193-200
Main Authors: Ohkura, Tsuyoshi, Fujioka, Youhei, Izawa, Shoichiro, Sumi, Keisuke, Yamamoto, Naoya, Shiochi, Hideki, Matsuzawa, Kazuhiko, Kinoshita, Hiroshi, Ohkura, Hiroko, Kato, Masahiko, Taniguchi, Shin-Ichi, Yamamoto, Kazuhiro
Format: Article
Language:English
Subjects:
Diabetes
Family Medicine
General Practice
Health Administration
Medicine
Medicine & Public Health
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Summary:Several studies report that endogenous insulin secretion (EIS) ability is correlated with BMI in glucagon stimulation tests (GST). Despite a standard method to assess EIS, GST can produce side effects such as nausea. Therefore, we investigated the relationship between EIS and BMI with a simple meal tolerance test (MTT). One-hundred type 2 diabetes mellitus (T2DM) patients (average: age 61, HbA1c 9.2 %, BMI 25.0 kg/m 2 , duration of DM 11.5 years) subjected to a MTT. We measured serum C-peptide immunoreactivity (CPR) at fasting, and 2 h after a calorie controlled breakfast, and calculated the difference to give ΔCPR. The fasting and postprandial CPR significantly correlated with BMI ( R  = 0.59, R  = 0.48, P  
ISSN:0973-3930
1998-3832
DOI:10.1007/s13410-013-0181-8