Cutaneous and systemic anti-allergic potential of xylopic acid in rodents

Xylopic acid is a kaurene diterpene isolated from the dried fruit of Xylopia aethiopica . It has been identified to exhibit analgesic activity and also demonstrates acute and chronic anti-inflammatory activity. This study aimed at investigating its potential anti-allergic activity using rodent model...

Full description

Saved in:
Bibliographic Details
Published in:Advances in traditional medicine (Online) 2022-09, Vol.22 (3), p.649-658
Main Authors: Osafo, Newman, Antwi, Aaron Opoku, Mante, Priscilla Kolibea, Osei, Yaa Asantewaa, Yeboah, Oduro Kofi, Otu-Boakye, Sarah
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Pharmacy
Research Article
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Xylopic acid is a kaurene diterpene isolated from the dried fruit of Xylopia aethiopica . It has been identified to exhibit analgesic activity and also demonstrates acute and chronic anti-inflammatory activity. This study aimed at investigating its potential anti-allergic activity using rodent models. To investigate this, antihistaminic study using guinea pig ileum preparation and clonidine-induced catalepsy model were employed. Also, cutaneous anaphylaxis was investigated using pinnal inflammation and compound 48/80-induced cutaneous anaphylaxis models. Systemic anaphylaxis was studied using compound 48/80 systemic anaphylaxis and lipopolysaccharide (LPS)-induced septic shock models. XA exerted H 1 antagonism in the ex vivo study using guinea pig ileum which supported its anti-histaminic activity in the clonidine-induced catalepsy. It also suppressed pinnal inflammation and inhibited mast cell degranulation and tissue damage significantly ( P  
ISSN:2662-4052
2662-4060
DOI:10.1007/s13596-021-00595-2