“On-water” organic synthesis: l-proline catalyzed synthesis of pyrimidine-2,4-dione-, benzo[g]- and dihydropyrano[2,3-g]chromene derivatives in aqueous media

In this work, functionalized pyrimidine-2,4-dione-, benzo[ g ]-, and dihydropyrano[2,3- g ]chromene derivatives have been synthesized via a Michael addition of 2-hydroxy-1,4-naphthoquinone or 2,5-dihydroxy-1,4-benzoquinone to the Knoevenagel condensation product of an aldehyde with Meldrum’s acid, d...

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Bibliographic Details
Published in:Journal of the Iranian Chemical Society 2013-04, Vol.10 (2), p.307-317
Main Authors: Mofakham, Hamid, Ghadari, Rahim, Shaabani, Ahmad, Pedarpour, Milad, Ghasemi, Sabrieh
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biochemistry
Chemistry
Chemistry and Materials Science
Inorganic Chemistry
Organic Chemistry
Original Paper
Physical Chemistry
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Summary:In this work, functionalized pyrimidine-2,4-dione-, benzo[ g ]-, and dihydropyrano[2,3- g ]chromene derivatives have been synthesized via a Michael addition of 2-hydroxy-1,4-naphthoquinone or 2,5-dihydroxy-1,4-benzoquinone to the Knoevenagel condensation product of an aldehyde with Meldrum’s acid, dimedone or barbituric acid in the presence of a catalytic amount of l -proline under refluxing conditions in water in good to excellent yields.
ISSN:1735-207X
1735-2428
DOI:10.1007/s13738-012-0160-x