ZnO nanoparticle-catalyzed efficient one-pot three-component synthesis of 3,4,5-trisubstituted furan-2(5H)-ones

An efficient and high-yielding protocol using nano-ZnO (50–100 nm) as an efficient heterogeneous catalyst for one-pot three-component synthesis of pharmacologically significant furanone derivatives by the condensation of aromatic aldehyde, amine and dimethylacetylenedicarboxylate has been developed....

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Bibliographic Details
Published in:Journal of the Iranian Chemical Society 2013-12, Vol.10 (6), p.1271-1277
Main Authors: Tekale, Sunil U., Kauthale, Sushma S., Pagore, Vijay P., Jadhav, Vivekanand B., Pawar, Rajendra P.
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biochemistry
Chemistry
Chemistry and Materials Science
Inorganic Chemistry
Organic Chemistry
Original Paper
Physical Chemistry
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Summary:An efficient and high-yielding protocol using nano-ZnO (50–100 nm) as an efficient heterogeneous catalyst for one-pot three-component synthesis of pharmacologically significant furanone derivatives by the condensation of aromatic aldehyde, amine and dimethylacetylenedicarboxylate has been developed. Since the catalyst is heterogeneous, it can be easily separated and recycled several times without much loss of its catalytic activity. Use of aqueous medium, recyclable nanocatalyst, operational simplicity, non-chromatographic purification technique, excellent yield and short reaction time makes this approach an attractive protocol for the synthesis of 3,4,5-trisubstituted furan-2(5H)-ones.
ISSN:1735-207X
1735-2428
DOI:10.1007/s13738-013-0266-9