An efficient synthesis of pyrano [2, 3-d] pyrimidines catalyzed by ZrO2-CeO2 nanoparticles and their anticancer evaluation

Zirconium doped cerium nanoparticles have been found to be an excellent heterogeneous catalyst for the one-pot multi-component reactions of Barbituric acid, aromatic aldehyde and malononitrile to yield the Pyrano(2,3-d) pyrimidine derivatives in aqueous media. The results showed that nanosized CeO 2...

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Bibliographic Details
Published in:Journal of the Iranian Chemical Society 2024-10, Vol.21 (10), p.2659-2667
Main Authors: Nagar, Aarti, Meena, Virendra Singh, Paliwal, Pradeep Kumar, Jain, Shubha
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biochemistry
Chemistry
Chemistry and Materials Science
Inorganic Chemistry
Organic Chemistry
Original Paper
Physical Chemistry
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Summary:Zirconium doped cerium nanoparticles have been found to be an excellent heterogeneous catalyst for the one-pot multi-component reactions of Barbituric acid, aromatic aldehyde and malononitrile to yield the Pyrano(2,3-d) pyrimidine derivatives in aqueous media. The results showed that nanosized CeO 2  − ZrO 2 has a potential catalytic material for the synthesis of title compound. All the synthesized molecules were determined and characterised by chromatographic and spectroscopic (IR, 1 H-NMR, 13 C-NMR, HR-MS) analysis. The formation, size and morphology of the metal ions present in the material is confirmed by powdered X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) techniques. The synthesised compounds have shown good to excellent cytotoxicity against human breast cancer cell line MDA-MB-453.
ISSN:1735-207X
1735-2428
DOI:10.1007/s13738-024-03097-5