Analysis of effects of different pesticides on mammalian system

Pesticides increase the yield in agriculture by controlling pests. Pesticides are applied during production, storage, transportation and distribution of food. Pesticide residues from food stuffs have been monitored in different parts of the country under the pesticide residues coordinated research p...

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Bibliographic Details
Published in:International journal of environmental science and technology (Tehran) 2024, Vol.21 (1), p.285-292
Main Authors: Divyashree, J., Tomar, S., Singh, A. P.
Format: Article
Language:English
Subjects:
Aquatic Pollution
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Science and Engineering
Original Paper
Soil Science & Conservation
Waste Water Technology
Water Management
Water Pollution Control
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Summary:Pesticides increase the yield in agriculture by controlling pests. Pesticides are applied during production, storage, transportation and distribution of food. Pesticide residues from food stuffs have been monitored in different parts of the country under the pesticide residues coordinated research project in India of the Indian Council of Agricultural Research, New Delhi. Apart from the benefits of pesticide, there may be great potential impact of trace amounts of pesticide residues on food commodities. Pesticides can broadly classify on chemical structure as organochlorine pesticide, organophosphate pesticide and synthetic pyrethroids. Liver plays an important role in metabolism to maintain energy level and structural stability of body. It is also a place of biotransformation where a toxic substance has been transformed to less dangerous form to minimize liver damage. Alanine transaminase (ALT), aspartate transaminase, alkaline phosphate (ALP) and acid phosphatase (ACP) are some hepatotoxicity markers, and an alternate in their activities in liver may be an indicator of liver damage or disease. To my study were selected endosulfan, phorate and fenvalerate representing each of the three main classes of insecticide to study various toxic effects induced by pesticides in mammalian system. Observed decrease in glutathione and GST levels in rats treated with pesticides demonstrates the oxidative damage produced by pesticide treatment. LDH activity also enhanced due to enzyme leakage. Increase in the activity of ACP, ALT and ALP indicates damage in liver tissues and function. Detection of GGT indicates oxidative stress.
ISSN:1735-1472
1735-2630
DOI:10.1007/s13762-023-04849-1